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    Higher tacrolimus trough levels on days 2-5 post-renal transplant are associated with reduced rates of acute rejection.

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    Authors
    O'Seaghdha, C M
    McQuillan, R
    Moran, A M
    Lavin, P
    Dorman, A
    O'Kelly, P
    Mohan, D M
    Little, P
    Hickey, D P
    Conlon, P J
    Affiliation
    Department of Nephrology and Transplantation, Beaumont Hospital, Dublin, Ireland.
    Issue Date
    2011-04-06T14:17:52Z
    MeSH
    Adolescent
    Adult
    Aged
    Cadaver
    Child
    Child, Preschool
    Drug Monitoring
    Drug Therapy, Combination
    Female
    Graft Rejection
    Graft Survival
    Humans
    Immunosuppressive Agents
    Kidney Transplantation
    Male
    Middle Aged
    Mycophenolic Acid
    Prednisolone
    Retrospective Studies
    Tacrolimus
    Young Adult
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    Citation
    Higher tacrolimus trough levels on days 2-5 post-renal transplant are associated with reduced rates of acute rejection., 23 (4):462-8 Clin Transplant
    Journal
    Clinical transplantation
    URI
    http://hdl.handle.net/10147/127487
    DOI
    10.1111/j.1399-0012.2009.01021.x
    PubMed ID
    19681975
    Abstract
    We analyzed the association between whole-blood trough tacrolimus (TAC) levels in the first days post-kidney transplant and acute cellular rejection (ACR) rates. Four hundred and sixty-four consecutive, deceased-donor kidney transplant recipients were included. All were treated with a combination of TAC, mycophenolate mofetil and prednisolone. Patients were analyzed in four groups based on quartiles of the mean TAC on days 2 and 5 post-transplant: Group 1: median TAC 11 ng/mL (n = 122, range 2-13.5 ng/mL), Group 2: median 17 ng/mL (n = 123, range 14-20 ng/mL), Group 3: median 24 ng/mL (n = 108, range 20.5-27 ng/mL) and Group 4: median 33.5 ng/mL (n = 116, range 27.5-77.5 ng/mL). A graded reduction in the rates of ACR was observed for each incremental days 2-5 TAC. The one-yr ACR rate was 24.03% (95% CI 17.26-32.88), 22.20% (95% CI 15.78-30.70), 13.41% (95% CI 8.15-21.63) and 8.69% (95% CI 4.77-15.55) for Groups 1-4, respectively (p = 0.003). This study suggests that higher early TACs are associated with reduced rates of ACR at one yr.
    Item Type
    Article
    Language
    en
    ISSN
    1399-0012
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1399-0012.2009.01021.x
    Scopus Count
    Collections
    Beaumont Hospital

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