Below knee angioplasty in elderly patients: Predictors of major adverse clinical outcomes.
dc.contributor.author | Keeling, Aoife N | |
dc.contributor.author | Khalidi, Karim | |
dc.contributor.author | Leong, Sum | |
dc.contributor.author | Wang, Tim T | |
dc.contributor.author | Ayyoub, Alaa S | |
dc.contributor.author | McGrath, Frank P | |
dc.contributor.author | Athanasiou, Thanos | |
dc.contributor.author | Lee, Michael J | |
dc.date.accessioned | 2011-04-05T15:32:57Z | |
dc.date.available | 2011-04-05T15:32:57Z | |
dc.date.issued | 2011-03 | |
dc.identifier.citation | Below knee angioplasty in elderly patients: Predictors of major adverse clinical outcomes. 2011, 77 (3):483-9 Eur J Radiol | en |
dc.identifier.issn | 1872-7727 | |
dc.identifier.pmid | 19765932 | |
dc.identifier.doi | 10.1016/j.ejrad.2009.08.011 | |
dc.identifier.uri | http://hdl.handle.net/10147/127272 | |
dc.description.abstract | To determine predictors of clinical outcome following percutaneous transluminal angioplasty (PTA) in elderly patients with below knee atherosclerotic lesions causing intermittent claudication (IC) or critical limb ischaemia (CLI). | |
dc.description.abstract | Over 7.5 years, 76 patients (CLI 72%, n=55) underwent below knee PTA. The composite end-point of interest was major adverse clinical outcome (MACO) of the treated limb at follow-up which was defined as clinical failure, need for subsequent endovascular or surgical revascularization or amputation. Actuarial freedom from MACO was assessed using Kaplan-Meier curves and multivariable Cox proportional hazards regression. | |
dc.description.abstract | IC was improved in 95% at mean 3.4 years (range 0.5-108 months). Successful limb salvage and ulcer healing were seen in 73% with CLI. Most failures were in the CLI group (27% CLI vs. 5% IC), with an amputation rate of 16% for CLI vs. 5% for IC and persistent ulceration in 24% of CLI. Significant independent predictors of MACO were ulceration (hazard ratio 4.02, 95% CI=1.55-10.38) and family history of atherosclerosis (hazard ratio 2.53, 95% CI=1.1-5.92). | |
dc.description.abstract | Primary below knee PTA is a feasible therapeutic option in this elderly population. Limb ulceration and family history of atherosclerosis may be independent predictors of adverse outcome. | |
dc.language.iso | en | en |
dc.title | Below knee angioplasty in elderly patients: Predictors of major adverse clinical outcomes. | en |
dc.type | Article In Press | en |
dc.contributor.department | Department of Academic Radiology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland. | en |
dc.identifier.journal | European journal of radiology | en |
dc.description.province | Leinster | |
html.description.abstract | To determine predictors of clinical outcome following percutaneous transluminal angioplasty (PTA) in elderly patients with below knee atherosclerotic lesions causing intermittent claudication (IC) or critical limb ischaemia (CLI). | |
html.description.abstract | Over 7.5 years, 76 patients (CLI 72%, n=55) underwent below knee PTA. The composite end-point of interest was major adverse clinical outcome (MACO) of the treated limb at follow-up which was defined as clinical failure, need for subsequent endovascular or surgical revascularization or amputation. Actuarial freedom from MACO was assessed using Kaplan-Meier curves and multivariable Cox proportional hazards regression. | |
html.description.abstract | IC was improved in 95% at mean 3.4 years (range 0.5-108 months). Successful limb salvage and ulcer healing were seen in 73% with CLI. Most failures were in the CLI group (27% CLI vs. 5% IC), with an amputation rate of 16% for CLI vs. 5% for IC and persistent ulceration in 24% of CLI. Significant independent predictors of MACO were ulceration (hazard ratio 4.02, 95% CI=1.55-10.38) and family history of atherosclerosis (hazard ratio 2.53, 95% CI=1.1-5.92). | |
html.description.abstract | Primary below knee PTA is a feasible therapeutic option in this elderly population. Limb ulceration and family history of atherosclerosis may be independent predictors of adverse outcome. |