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dc.contributor.authorThomas, Warren
dc.contributor.authorDooley, Ruth
dc.contributor.authorHarvey, Brian J
dc.date.accessioned2011-04-05T15:26:18Z
dc.date.available2011-04-05T15:26:18Z
dc.date.issued2011-04-05T15:26:18Z
dc.identifier.citationAldosterone as a renal growth factor., 75 (8-9):550-4 Steroidsen
dc.identifier.issn1878-5867
dc.identifier.pmid19782095
dc.identifier.doi10.1016/j.steroids.2009.09.008
dc.identifier.urihttp://hdl.handle.net/10147/127269
dc.description.abstractAldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis. Aldosterone directly modulates renal cell proliferation and differentiation as part of normal kidney development. The stimulation of rapidly activated protein kinase cascades is one facet of how aldosterone regulates renal cell growth. These cascades may also contribute to myofibroblastic transformation and cell proliferation observed in pathological conditions of the kidney. Polycystic kidney disease is a genetic disorder that is accelerated by hypertension. EGFR-dependent proliferation of the renal epithelium is a factor in cyst development and trans-activation of EGFR is a key feature in initiating aldosterone-induced signalling cascades. Delineating the components of aldosterone-induced signalling cascades may identify novel therapeutic targets for proliferative diseases of the kidney.
dc.language.isoenen
dc.subject.meshAldosterone
dc.subject.meshAnimals
dc.subject.meshCell Proliferation
dc.subject.meshHumans
dc.subject.meshKidney
dc.subject.meshKidney Diseases
dc.subject.meshReceptor, Epidermal Growth Factor
dc.subject.meshSignal Transduction
dc.titleAldosterone as a renal growth factor.en
dc.typeArticleen
dc.contributor.departmentDepartment of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. wthomas@rcsi.ieen
dc.identifier.journalSteroidsen
dc.description.provinceLeinster
html.description.abstractAldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis. Aldosterone directly modulates renal cell proliferation and differentiation as part of normal kidney development. The stimulation of rapidly activated protein kinase cascades is one facet of how aldosterone regulates renal cell growth. These cascades may also contribute to myofibroblastic transformation and cell proliferation observed in pathological conditions of the kidney. Polycystic kidney disease is a genetic disorder that is accelerated by hypertension. EGFR-dependent proliferation of the renal epithelium is a factor in cyst development and trans-activation of EGFR is a key feature in initiating aldosterone-induced signalling cascades. Delineating the components of aldosterone-induced signalling cascades may identify novel therapeutic targets for proliferative diseases of the kidney.


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