Name:
Publisher version
View Source
Access full-text PDFOpen Access
View Source
Check access options
Check access options
Affiliation
Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. wthomas@rcsi.ieIssue Date
2011-04-05T15:26:18ZMeSH
AldosteroneAnimals
Cell Proliferation
Humans
Kidney
Kidney Diseases
Receptor, Epidermal Growth Factor
Signal Transduction
Metadata
Show full item recordCitation
Aldosterone as a renal growth factor., 75 (8-9):550-4 SteroidsJournal
SteroidsDOI
10.1016/j.steroids.2009.09.008PubMed ID
19782095Abstract
Aldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis. Aldosterone directly modulates renal cell proliferation and differentiation as part of normal kidney development. The stimulation of rapidly activated protein kinase cascades is one facet of how aldosterone regulates renal cell growth. These cascades may also contribute to myofibroblastic transformation and cell proliferation observed in pathological conditions of the kidney. Polycystic kidney disease is a genetic disorder that is accelerated by hypertension. EGFR-dependent proliferation of the renal epithelium is a factor in cyst development and trans-activation of EGFR is a key feature in initiating aldosterone-induced signalling cascades. Delineating the components of aldosterone-induced signalling cascades may identify novel therapeutic targets for proliferative diseases of the kidney.Item Type
ArticleLanguage
enISSN
1878-5867ae974a485f413a2113503eed53cd6c53
10.1016/j.steroids.2009.09.008
Scopus Count
Collections
Related articles
- Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis.
- Authors: Benter IF, Canatan H, Benboubetra M, Yousif MH, Akhtar S
- Issue date: 2009 Aug-Sep
- Aldosterone-stimulated PKC signalling cascades: from receptor to effector.
- Authors: Thomas W, McEneaney V, Harvey BJ
- Issue date: 2007 Nov
- Aldosterone-induced EGFR expression: interaction between the human mineralocorticoid receptor and the human EGFR promoter.
- Authors: Grossmann C, Krug AW, Freudinger R, Mildenberger S, Voelker K, Gekle M
- Issue date: 2007 Jun
- Aldosterone regulates cellular turnover and mitogen-activated protein kinase family expression in the neonatal rat kidney.
- Authors: Yim HE, Yoo KH, Bae IS, Jang GY, Hong YS, Lee JW
- Issue date: 2009 Jun
- Epidermal growth factor receptor in cultured human retinal pigment epithelial cells.
- Authors: Yan F, Hui YN, Li YJ, Guo CM, Meng H
- Issue date: 2007