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    Aldosterone as a renal growth factor.

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    Authors
    Thomas, Warren
    Dooley, Ruth
    Harvey, Brian J
    Affiliation
    Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland. wthomas@rcsi.ie
    Issue Date
    2011-04-05T15:26:18Z
    MeSH
    Aldosterone
    Animals
    Cell Proliferation
    Humans
    Kidney
    Kidney Diseases
    Receptor, Epidermal Growth Factor
    Signal Transduction
    
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    Citation
    Aldosterone as a renal growth factor., 75 (8-9):550-4 Steroids
    Journal
    Steroids
    URI
    http://hdl.handle.net/10147/127269
    DOI
    10.1016/j.steroids.2009.09.008
    PubMed ID
    19782095
    Abstract
    Aldosterone regulates blood pressure through its effects on the cardiovascular system and kidney. Aldosterone can also contribute to the development of hypertension that leads to chronic pathologies such as nephropathy and renal fibrosis. Aldosterone directly modulates renal cell proliferation and differentiation as part of normal kidney development. The stimulation of rapidly activated protein kinase cascades is one facet of how aldosterone regulates renal cell growth. These cascades may also contribute to myofibroblastic transformation and cell proliferation observed in pathological conditions of the kidney. Polycystic kidney disease is a genetic disorder that is accelerated by hypertension. EGFR-dependent proliferation of the renal epithelium is a factor in cyst development and trans-activation of EGFR is a key feature in initiating aldosterone-induced signalling cascades. Delineating the components of aldosterone-induced signalling cascades may identify novel therapeutic targets for proliferative diseases of the kidney.
    Item Type
    Article
    Language
    en
    ISSN
    1878-5867
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.steroids.2009.09.008
    Scopus Count
    Collections
    Beaumont Hospital

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