Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery.
Affiliation
Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland. cmgreene@rcsi.ieIssue Date
2009-10MeSH
AnimalsChronic Disease
Drug Discovery
Humans
Lung Diseases
Peptide Hydrolases
Protease Inhibitors
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Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery. 2009, 158 (4):1048-58 Br. J. Pharmacol.Journal
British journal of pharmacologyDOI
10.1111/j.1476-5381.2009.00448.xPubMed ID
19845686Abstract
Chronic inflammatory lung diseases such as cystic fibrosis and emphysema are characterized by higher-than-normal levels of pulmonary proteases. While these enzymes play important roles such as bacterial killing, their dysregulated expression or activity can adversely impact on the inflammatory process. The existence of efficient endogenous control mechanisms that can dampen or halt this overexuberant protease activity in vivo is essential for the effective resolution of inflammatory lung disease. The function of pulmonary antiproteases is to fulfil this role. Interestingly, in addition to their antiprotease activity, protease inhibitors in the lung also often possess other intrinsic properties that contribute to microbial killing or termination of the inflammatory process. This review will outline important features of chronic inflammation that are regulated by pulmonary proteases and will describe the various mechanisms by which antiproteases attempt to counterbalance exaggerated protease-mediated inflammatory events. These proteases, antiproteases and their modifiers represent interesting targets for therapeutic intervention.Item Type
ArticleLanguage
enISSN
1476-5381ae974a485f413a2113503eed53cd6c53
10.1111/j.1476-5381.2009.00448.x
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