Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery.
AffiliationRespiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland. firstname.lastname@example.org
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CitationProteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery. 2009, 158 (4):1048-58 Br. J. Pharmacol.
JournalBritish journal of pharmacology
AbstractChronic inflammatory lung diseases such as cystic fibrosis and emphysema are characterized by higher-than-normal levels of pulmonary proteases. While these enzymes play important roles such as bacterial killing, their dysregulated expression or activity can adversely impact on the inflammatory process. The existence of efficient endogenous control mechanisms that can dampen or halt this overexuberant protease activity in vivo is essential for the effective resolution of inflammatory lung disease. The function of pulmonary antiproteases is to fulfil this role. Interestingly, in addition to their antiprotease activity, protease inhibitors in the lung also often possess other intrinsic properties that contribute to microbial killing or termination of the inflammatory process. This review will outline important features of chronic inflammation that are regulated by pulmonary proteases and will describe the various mechanisms by which antiproteases attempt to counterbalance exaggerated protease-mediated inflammatory events. These proteases, antiproteases and their modifiers represent interesting targets for therapeutic intervention.
- [Proteases, antiproteases and pulmonary emphysema].
- Authors: Pelletier A, Pauli G, Bieth JG
- Issue date: 1982
- Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease.
- Authors: McKelvey MC, Brown R, Ryan S, Mall MA, Weldon S, Taggart CC
- Issue date: 2021 May 9
- Respiratory protease/antiprotease balance determines susceptibility to viral infection and can be modified by nutritional antioxidants.
- Authors: Meyer M, Jaspers I
- Issue date: 2015 Jun 15
- The Role of Serine Proteases and Antiproteases in the Cystic Fibrosis Lung.
- Authors: Twigg MS, Brockbank S, Lowry P, FitzGerald SP, Taggart C, Weldon S
- Issue date: 2015
- [Proteases, antiproteases, lung emphysema and other smoking damage].
- Authors: Sehayek E, Halkin H
- Issue date: 1989 Aug