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    Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery.

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    Authors
    Greene, Catherine M
    McElvaney, Noel G
    Affiliation
    Respiratory Research Division, Department of Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin, Ireland. cmgreene@rcsi.ie
    Issue Date
    2009-10
    MeSH
    Animals
    Chronic Disease
    Drug Discovery
    Humans
    Lung Diseases
    Peptide Hydrolases
    Protease Inhibitors
    
    Metadata
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    Citation
    Proteases and antiproteases in chronic neutrophilic lung disease - relevance to drug discovery. 2009, 158 (4):1048-58 Br. J. Pharmacol.
    Journal
    British journal of pharmacology
    URI
    http://hdl.handle.net/10147/127244
    DOI
    10.1111/j.1476-5381.2009.00448.x
    PubMed ID
    19845686
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2785526/pdf/bph0158-1048.pdf
    Abstract
    Chronic inflammatory lung diseases such as cystic fibrosis and emphysema are characterized by higher-than-normal levels of pulmonary proteases. While these enzymes play important roles such as bacterial killing, their dysregulated expression or activity can adversely impact on the inflammatory process. The existence of efficient endogenous control mechanisms that can dampen or halt this overexuberant protease activity in vivo is essential for the effective resolution of inflammatory lung disease. The function of pulmonary antiproteases is to fulfil this role. Interestingly, in addition to their antiprotease activity, protease inhibitors in the lung also often possess other intrinsic properties that contribute to microbial killing or termination of the inflammatory process. This review will outline important features of chronic inflammation that are regulated by pulmonary proteases and will describe the various mechanisms by which antiproteases attempt to counterbalance exaggerated protease-mediated inflammatory events. These proteases, antiproteases and their modifiers represent interesting targets for therapeutic intervention.
    Item Type
    Article
    Language
    en
    ISSN
    1476-5381
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1476-5381.2009.00448.x
    Scopus Count
    Collections
    Beaumont Hospital

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