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    Taurine modulates neutrophil function but potentiates uropathogenic E. coli infection in the murine bladder.

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    Authors
    Condron, Claire
    Casey, Rowan G
    Kehoe, Siobhan
    Toomey, Deirdre
    Creagh, Tom
    Bouchier-Hayes, David J
    Affiliation
    Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland.
    Issue Date
    2010-08
    MeSH
    Animals
    Disease Models, Animal
    Escherichia coli
    Escherichia coli Infections
    Female
    Mice
    Mice, Inbred C57BL
    Neutrophil Infiltration
    Neutrophils
    Taurine
    Urinary Bladder
    Urinary Tract Infections
    Urothelium
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    Citation
    Taurine modulates neutrophil function but potentiates uropathogenic E. coli infection in the murine bladder. 2010, 38 (4):215-22 Urol. Res.
    Journal
    Urological research
    URI
    http://hdl.handle.net/10147/127198
    DOI
    10.1007/s00240-009-0235-z
    PubMed ID
    19940987
    Abstract
    Eradication of a urinary tract infection (UTI) appears to be related to a number of innate host defence mechanisms and their interactions with invading bacteria. Recurrent UTIs (rUTIs) pose a difficult problem in that these bacteria use both host and bacterial factors to evade elimination. Neutrophil bactericidal function is depressed, both systemically and in urine, in patients with a history of recurrent UTI. Taurine is a semi-essential amino acid and is successful in preserving neutrophil bactericidal function in urine. Taurine may preserve neutrophil function at the urothelium and thus aid UTI resolution. Adult female (6 weeks old) C57Bl/6 mice were randomised into three groups: a saline gavage only control group, a saline gavage + E. coli group, and a taurine gavage + E. coli group [21 g/70 kg taurine in 0.9% normal saline (N/S) for 5 days]. Whilst taurine gavage pre-treatment resulted in increased serum neutrophils respiratory burst activity, at the urothelial-endothelial interface it caused higher colony forming units in the urine and a higher incidence of E. coli invasion in the bladder wall with no evidence of increased bladder wall neutrophils infiltration on MPO assay of histological assessment. Histologically there was also evidence of reduced bladder inflammation and urothelial cell apoptosis. In conclusion, taurine effectively increases neutrophils activity but given its anti-inflammatory properties, at the expense of decreased urothelial-endothelial activation thus preventing clearance of active E. coli infection in the bladder. Despite the negative results, this study demonstrates the importance of modulating interactions at the urothelial interface.
    Item Type
    Article
    Language
    en
    ISSN
    1434-0879
    ae974a485f413a2113503eed53cd6c53
    10.1007/s00240-009-0235-z
    Scopus Count
    Collections
    Beaumont Hospital

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