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dc.contributor.authorHarley, M
dc.contributor.authorKelleher, I
dc.contributor.authorClarke, M
dc.contributor.authorLynch, F
dc.contributor.authorArseneault, L
dc.contributor.authorConnor, D
dc.contributor.authorFitzpatrick, C
dc.contributor.authorCannon, M
dc.date.accessioned2011-04-05T14:22:23Z
dc.date.available2011-04-05T14:22:23Z
dc.date.issued2010-10
dc.identifier.citationCannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence. 2010, 40 (10):1627-34 Psychol Meden
dc.identifier.issn1469-8978
dc.identifier.pmid19995476
dc.identifier.doi10.1017/S0033291709991966
dc.identifier.urihttp://hdl.handle.net/10147/127193
dc.description.abstractAdolescent cannabis use has been shown in many studies to increase the risk of later psychosis. Childhood trauma is associated with both substance misuse and risk for psychosis. In this study our aim was to investigate whether there is a significant interaction between cannabis use and childhood trauma in increasing the risk for experiencing psychotic symptoms during adolescence.
dc.description.abstractPsychiatric interviews using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS) semi-structured instrument were carried out with 211 adolescents aged between 12 and 15 years and their parents as part of a population-based study. The interview enquired about early traumatic events, cannabis use and psychiatric symptoms in adolescence.
dc.description.abstractIn separate analyses both cannabis use and childhood trauma were significantly associated with risk of experiencing psychotic symptoms. However, the presence of both childhood trauma and early cannabis use significantly increased the risk for psychotic symptoms beyond the risk posed by either risk factor alone, indicating that there was a greater than additive interaction between childhood trauma and cannabis use.
dc.description.abstractOur finding of a greater than additive interaction between childhood trauma and cannabis use may have implications for the identification of individuals at high risk of experiencing psychotic symptoms. For example, measures to actively discourage or intensively treat cannabis use in children and adolescents who have experienced abuse may help to prevent the development of psychosis in this vulnerable group. Our findings require replication in larger samples to confirm this interaction effect.
dc.language.isoenen
dc.subject.meshAdolescent
dc.subject.meshAge of Onset
dc.subject.meshChild
dc.subject.meshChild Abuse
dc.subject.meshChild Abuse, Sexual
dc.subject.meshDomestic Violence
dc.subject.meshFamily Relations
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMarijuana Abuse
dc.subject.meshParents
dc.subject.meshPsychiatric Status Rating Scales
dc.subject.meshPsychotic Disorders
dc.subject.meshRisk Factors
dc.subject.meshSocioeconomic Factors
dc.titleCannabis use and childhood trauma interact additively to increase the risk of psychotic symptoms in adolescence.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.en
dc.identifier.journalPsychological medicineen
dc.description.provinceLeinster
html.description.abstractAdolescent cannabis use has been shown in many studies to increase the risk of later psychosis. Childhood trauma is associated with both substance misuse and risk for psychosis. In this study our aim was to investigate whether there is a significant interaction between cannabis use and childhood trauma in increasing the risk for experiencing psychotic symptoms during adolescence.
html.description.abstractPsychiatric interviews using the Schedule for Affective Disorders and Schizophrenia for School-Age Children (K-SADS) semi-structured instrument were carried out with 211 adolescents aged between 12 and 15 years and their parents as part of a population-based study. The interview enquired about early traumatic events, cannabis use and psychiatric symptoms in adolescence.
html.description.abstractIn separate analyses both cannabis use and childhood trauma were significantly associated with risk of experiencing psychotic symptoms. However, the presence of both childhood trauma and early cannabis use significantly increased the risk for psychotic symptoms beyond the risk posed by either risk factor alone, indicating that there was a greater than additive interaction between childhood trauma and cannabis use.
html.description.abstractOur finding of a greater than additive interaction between childhood trauma and cannabis use may have implications for the identification of individuals at high risk of experiencing psychotic symptoms. For example, measures to actively discourage or intensively treat cannabis use in children and adolescents who have experienced abuse may help to prevent the development of psychosis in this vulnerable group. Our findings require replication in larger samples to confirm this interaction effect.


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