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    Felbamate in an adult population with severe refractory epilepsy.

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    Authors
    Kearney, H
    Delanty, N
    Affiliation
    Department of Neurology, Beaumont Hospital, Beaumont, Dublin. hughkearney@yahoo.com
    Issue Date
    2011-04-05T11:15:56Z
    MeSH
    Adult
    Anticonvulsants
    Epilepsy
    Female
    Humans
    Ireland
    Male
    Middle Aged
    Phenylcarbamates
    Propylene Glycols
    Retrospective Studies
    Treatment Outcome
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    Citation
    Felbamate in an adult population with severe refractory epilepsy., 102 (10):326-8 Ir Med J
    Journal
    Irish medical journal
    URI
    http://hdl.handle.net/10147/127093
    PubMed ID
    20108801
    Abstract
    Felbamate (FBM) is efficacious in treating patients with refractory epilepsy but was withdrawn due to cases of aplastic anaemia, hepatic failure and five reported deaths. FBM is currently used in specialist centres and is only being used in one Irish centre to date. This papers aim is to review the efficacy and safety experience of FBM in Irish adult patients with refractory epilepsy. A retrospective chart review was done on patients' medical records. Patients were subdivided into responders and non responders based on change in seizure frequency and side effects were recorded for all. Of the 13 patients on FBM nine patients responded to FBM, four patients did not. FBM is a safe and efficacious alternative in an Irish adult population with refractory epilepsy. However close monitoring is still required given the potential fatal side effects that are possible with this anticonvulsant.
    Item Type
    Article
    Language
    en
    ISSN
    0332-3102
    Collections
    Beaumont Hospital

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