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    The role of menin in parathyroid tumorigenesis.

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    Authors
    Davenport, Colin
    Agha, Amar
    Affiliation
    Academic Department of Endocrinology, Beaumont Hospital and Royal College of Surgeons in Ireland Medical School, Beaumont Road, Dublin 9, Ireland.
    Issue Date
    2009
    MeSH
    Humans
    Hyperparathyroidism, Primary
    Multiple Endocrine Neoplasia Type 1
    Mutation
    Parathyroid Glands
    Parathyroid Hormone
    Parathyroid Neoplasms
    Proto-Oncogene Proteins
    Signal Transduction
    Smad Proteins
    Transforming Growth Factor beta
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    Citation
    The role of menin in parathyroid tumorigenesis. 2009, 668:79-86 Adv. Exp. Med. Biol.
    Journal
    Advances in experimental medicine and biology
    URI
    http://hdl.handle.net/10147/127088
    PubMed ID
    20175455
    Abstract
    Primary hyperparathyroidism is a common disorder that involves the pathological enlargement of one or more parathyroid glands resulting in excessive production of parathyroid hormone (PTH). The exact pathogenesis of this disease remains to be fully understood. In recent years interest has focussed on the interaction between menin protein and the transforming growth factor (TGF)-beta/Smad signalling pathway. In vitro experimentation has demonstrated that the presence of menin is required for TGF-beta to effectively inhibit parathyroid cell proliferation and PTH production. This observation correlates with the almost universal occurrence of parathyroid tumors accompanying the inactivation of menin in multiple endocrine neoplasia Type 1 (MEN1) syndrome and the high rate of somatic menin gene mutations seen in sporadic parathyroid adenomas. This chapter aims to review the role of menin in primary hyperparathyroidism and parathyroid hormone-regulation, including the influences of MEN1 gene mutations on parathyroid cell proliferation, differentiation and tumorigenesis.
    Item Type
    Article
    Language
    en
    ISSN
    0065-2598
    Collections
    Beaumont Hospital

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