AffiliationAcademic Department of Endocrinology, Beaumont Hospital and Royal College of Surgeons in Ireland Medical School, Beaumont Road, Dublin 9, Ireland.
Multiple Endocrine Neoplasia Type 1
Transforming Growth Factor beta
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CitationThe role of menin in parathyroid tumorigenesis. 2009, 668:79-86 Adv. Exp. Med. Biol.
JournalAdvances in experimental medicine and biology
AbstractPrimary hyperparathyroidism is a common disorder that involves the pathological enlargement of one or more parathyroid glands resulting in excessive production of parathyroid hormone (PTH). The exact pathogenesis of this disease remains to be fully understood. In recent years interest has focussed on the interaction between menin protein and the transforming growth factor (TGF)-beta/Smad signalling pathway. In vitro experimentation has demonstrated that the presence of menin is required for TGF-beta to effectively inhibit parathyroid cell proliferation and PTH production. This observation correlates with the almost universal occurrence of parathyroid tumors accompanying the inactivation of menin in multiple endocrine neoplasia Type 1 (MEN1) syndrome and the high rate of somatic menin gene mutations seen in sporadic parathyroid adenomas. This chapter aims to review the role of menin in primary hyperparathyroidism and parathyroid hormone-regulation, including the influences of MEN1 gene mutations on parathyroid cell proliferation, differentiation and tumorigenesis.
- Menin inactivation leads to loss of transforming growth factor beta inhibition of parathyroid cell proliferation and parathyroid hormone secretion.
- Authors: Sowa H, Kaji H, Kitazawa R, Kitazawa S, Tsukamoto T, Yano S, Tsukada T, Canaff L, Hendy GN, Sugimoto T, Chihara K
- Issue date: 2004 Mar 15
- Menin and bone metabolism.
- Authors: Kaji H
- Issue date: 2012 Jul
- Menin and TGF-beta superfamily member signaling via the Smad pathway in pituitary, parathyroid and osteoblast.
- Authors: Hendy GN, Kaji H, Sowa H, Lebrun JJ, Canaff L
- Issue date: 2005 Jun
- Expression and functional analysis of menin in a multiple endocrine neoplasia type 1 (MEN1) patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 gene.
- Authors: Naito J, Kaji H, Sowa H, Kitazawa R, Kitazawa S, Tsukada T, Hendy GN, Sugimoto T, Chihara K
- Issue date: 2006 Jun
- Impaired transforming growth factor-β (TGF-β) transcriptional activity and cell proliferation control of a menin in-frame deletion mutant associated with multiple endocrine neoplasia type 1 (MEN1).
- Authors: Canaff L, Vanbellinghen JF, Kaji H, Goltzman D, Hendy GN
- Issue date: 2012 Mar 9