Osteonecrosis of the jaw: a rare and devastating side effect of bisphosphonates.
Affiliation
Oral & Maxillofacial Surgery Department, St James's Hospital, Dublin 8, Ireland. ryan.patrick.1@gmail.comIssue Date
2009-12MeSH
Antineoplastic AgentsDiagnosis, Differential
Diphosphonates
Humans
Jaw Diseases
Neoplasms
Osteonecrosis
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Osteonecrosis of the jaw: a rare and devastating side effect of bisphosphonates. 2009, 85 (1010):674-7 Postgrad Med JJournal
Postgraduate medical journalDOI
10.1136/pgmj.2008.076349PubMed ID
20075406Abstract
Evidence has emerged that bisphosphonate use in cancer patients is associated with osteonecrosis of the jaw. This form of osteonecrosis has been termed bisphosphonate induced osteonecrosis of the jaw (BIONJ). BIONJ is commonly precipitated by a tooth extraction in patients treated with long term, potent, high dose intravenous bisphosphonates for the management of myeloma, breast or prostate cancer. The overall prevalence of BIONJ is about 5% in patients with these malignancies. Current evidence shows that the risk of BIONJ in non-cancerous patients, such as those with osteoporosis, is very low and appears to be comparable with that of the general population. Prescribing physicians need to encourage cancer patients to see their dentists before the initiation of bisphosphonate treatment, and regularly thereafter.Item Type
ArticleLanguage
enISSN
1469-0756ae974a485f413a2113503eed53cd6c53
10.1136/pgmj.2008.076349
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