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    Osteonecrosis of the jaw: a rare and devastating side effect of bisphosphonates.

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    Authors
    Ryan, P
    Saleh, I
    Stassen, L F A
    Affiliation
    Oral & Maxillofacial Surgery Department, St James's Hospital, Dublin 8, Ireland. ryan.patrick.1@gmail.com
    Issue Date
    2009-12
    MeSH
    Antineoplastic Agents
    Diagnosis, Differential
    Diphosphonates
    Humans
    Jaw Diseases
    Neoplasms
    Osteonecrosis
    
    Metadata
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    Citation
    Osteonecrosis of the jaw: a rare and devastating side effect of bisphosphonates. 2009, 85 (1010):674-7 Postgrad Med J
    Journal
    Postgraduate medical journal
    URI
    http://hdl.handle.net/10147/126989
    DOI
    10.1136/pgmj.2008.076349
    PubMed ID
    20075406
    Abstract
    Evidence has emerged that bisphosphonate use in cancer patients is associated with osteonecrosis of the jaw. This form of osteonecrosis has been termed bisphosphonate induced osteonecrosis of the jaw (BIONJ). BIONJ is commonly precipitated by a tooth extraction in patients treated with long term, potent, high dose intravenous bisphosphonates for the management of myeloma, breast or prostate cancer. The overall prevalence of BIONJ is about 5% in patients with these malignancies. Current evidence shows that the risk of BIONJ in non-cancerous patients, such as those with osteoporosis, is very low and appears to be comparable with that of the general population. Prescribing physicians need to encourage cancer patients to see their dentists before the initiation of bisphosphonate treatment, and regularly thereafter.
    Item Type
    Article
    Language
    en
    ISSN
    1469-0756
    ae974a485f413a2113503eed53cd6c53
    10.1136/pgmj.2008.076349
    Scopus Count
    Collections
    Dublin Dental University Hospital

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