Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy.
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Authors
Tapp, Robyn JSharp, Andrew
Stanton, Alice V
O'Brien, Eoin
Chaturvedi, Nishi
Poulter, Neil R
Sever, Peter S
Thom, Simon A McG
Hughes, Alun D
Mayet, Jamil
Affiliation
International Centre for Circulatory Health, NHLI, St. Mary's Hospital and Imperial College London, St. Mary'sCampus, London, United Kingdom. r.tapp@imperial.ac.ukIssue Date
2010-04-27MeSH
AmlodipineAntihypertensive Agents
Atenolol
Blood Pressure
Diastole
Echocardiography, Doppler
Female
Humans
Male
Middle Aged
Natriuretic Peptide, Brain
Ventricular Function, Left
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Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy. 2010, 55 (17):1875-81 J. Am. Coll. Cardiol.Journal
Journal of the American College of CardiologyDOI
10.1016/j.jacc.2009.11.084PubMed ID
20413040Abstract
We hypothesized that an amlodipine-based regimen would have more favorable effects on left ventricular (LV) diastolic function.Different antihypertensive therapies may vary in their effect on LV diastolic function.
The HACVD (Hypertension Associated Cardiovascular Disease) substudy of ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) collected detailed cardiovascular phenotypic data on a subset of 1,006 participants recruited from 2 centers (St. Mary's Hospital, London, and Beaumont Hospital, Dublin). Conventional and tissue Doppler echocardiography and measurement of plasma B-type natriuretic peptide (BNP) were performed approximately 1 year after randomization to atenolol-based or amlodipine-based antihypertensive treatment to assess LV diastolic function.
On-treatment blood pressure (BP) (mean +/- SD) was similar in both groups: atenolol-based regimen, systolic BP of 137 +/- 17 mm Hg, diastolic BP of 82 +/- 9 mm Hg; amlodipine-based regimen, systolic BP of 136 +/- 15 mm Hg, diastolic BP of 80 +/- 9 mm Hg. Ejection fraction did not differ between groups, but early diastolic mitral annular velocity (E'), a measure of diastolic relaxation, was lower in patients on the atenolol-based regimen: atenolol-based regimen, 7.9 +/- 1.8; amlodipine-based regimen, 8.8 +/- 2.0. A measure of left ventricular filling pressure, E/E', and BNP were significantly higher in patients on the atenolol-based regimen. Differences in E', E/E', and BNP remained significant after adjustment for age and sex. Further adjustment for systolic BP, LV mass index, and heart rate had no impact on differences in mean E' or BNP. The difference in E/E' was attenuated.
Patients receiving treatment with an amlodipine-based regimen had better diastolic function than patients treated with the atenolol-based regimen. Treatment-related differences in diastolic function were independent of BP reduction and other factors that are known to affect diastolic function.
Item Type
ArticleLanguage
enISSN
1558-3597ae974a485f413a2113503eed53cd6c53
10.1016/j.jacc.2009.11.084
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