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    Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy.

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    Authors
    Tapp, Robyn J
    Sharp, Andrew
    Stanton, Alice V
    O'Brien, Eoin
    Chaturvedi, Nishi
    Poulter, Neil R
    Sever, Peter S
    Thom, Simon A McG
    Hughes, Alun D
    Mayet, Jamil
    Affiliation
    International Centre for Circulatory Health, NHLI, St. Mary's Hospital and Imperial College London, St. Mary'sCampus, London, United Kingdom. r.tapp@imperial.ac.uk
    Issue Date
    2010-04-27
    MeSH
    Amlodipine
    Antihypertensive Agents
    Atenolol
    Blood Pressure
    Diastole
    Echocardiography, Doppler
    Female
    Humans
    Male
    Middle Aged
    Natriuretic Peptide, Brain
    Ventricular Function, Left
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    Citation
    Differential effects of antihypertensive treatment on left ventricular diastolic function: an ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) substudy. 2010, 55 (17):1875-81 J. Am. Coll. Cardiol.
    Journal
    Journal of the American College of Cardiology
    URI
    http://hdl.handle.net/10147/126568
    DOI
    10.1016/j.jacc.2009.11.084
    PubMed ID
    20413040
    Abstract
    We hypothesized that an amlodipine-based regimen would have more favorable effects on left ventricular (LV) diastolic function.
    Different antihypertensive therapies may vary in their effect on LV diastolic function.
    The HACVD (Hypertension Associated Cardiovascular Disease) substudy of ASCOT (Anglo-Scandinavian Cardiac Outcomes Trial) collected detailed cardiovascular phenotypic data on a subset of 1,006 participants recruited from 2 centers (St. Mary's Hospital, London, and Beaumont Hospital, Dublin). Conventional and tissue Doppler echocardiography and measurement of plasma B-type natriuretic peptide (BNP) were performed approximately 1 year after randomization to atenolol-based or amlodipine-based antihypertensive treatment to assess LV diastolic function.
    On-treatment blood pressure (BP) (mean +/- SD) was similar in both groups: atenolol-based regimen, systolic BP of 137 +/- 17 mm Hg, diastolic BP of 82 +/- 9 mm Hg; amlodipine-based regimen, systolic BP of 136 +/- 15 mm Hg, diastolic BP of 80 +/- 9 mm Hg. Ejection fraction did not differ between groups, but early diastolic mitral annular velocity (E'), a measure of diastolic relaxation, was lower in patients on the atenolol-based regimen: atenolol-based regimen, 7.9 +/- 1.8; amlodipine-based regimen, 8.8 +/- 2.0. A measure of left ventricular filling pressure, E/E', and BNP were significantly higher in patients on the atenolol-based regimen. Differences in E', E/E', and BNP remained significant after adjustment for age and sex. Further adjustment for systolic BP, LV mass index, and heart rate had no impact on differences in mean E' or BNP. The difference in E/E' was attenuated.
    Patients receiving treatment with an amlodipine-based regimen had better diastolic function than patients treated with the atenolol-based regimen. Treatment-related differences in diastolic function were independent of BP reduction and other factors that are known to affect diastolic function.
    Item Type
    Article
    Language
    en
    ISSN
    1558-3597
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jacc.2009.11.084
    Scopus Count
    Collections
    Beaumont Hospital

    entitlement

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