Cerebral tuberculoma in a patient receiving anti-TNF alpha (adalimumab) treatment.
AffiliationDepartment of Neuropathology, Beaumont Hospital, Beaumont, Dublin 9, Ireland. firstname.lastname@example.org
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CitationCerebral tuberculoma in a patient receiving anti-TNF alpha (adalimumab) treatment. 2010, 29 (10):1201-4 Clin. Rheumatol.
AbstractWe report a case of a cerebral tuberculoma in a 60-year-old woman with rheumatoid arthritis while receiving the anti-tumor necrosis factor alpha monoclonal antibody, adalimumab (Humira), for active disease. MR brain imaging for dyspraxia revealed a left parietal ring-enhancing lesion, which on resection was shown to be a necrotizing granuloma. There were no associated pulmonary lesions, and the patient was systemically well. Sputum and urine cultures were negative for tuberculosis. The patient was treated with anti-tuberculous medications and made an excellent recovery. We consider this to be the first documented case of tuberculosis involving the central nervous system occurring in the setting of adalimumab treatment.