• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4715
    UlsterS
    4715
    Connacht
    1603
    Munster
    48
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Display statistics

    Iodinated contrast media alter immune responses in pro-inflammatory states.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    O'Donnell, David H
    Moloney, Michael A
    Bouchier-Hayes, David J
    Lee, Michael J
    Affiliation
    Department of Radiology and Vascular Surgery, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland.
    Issue Date
    2010-07
    MeSH
    Animals
    Cell Adhesion
    Contrast Media
    Endothelial Cells
    Endotoxins
    Halogenation
    Immunity, Cellular
    Inflammation
    Iodine
    Leukocytes
    Male
    Osmolar Concentration
    Rats
    Rats, Sprague-Dawley
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Iodinated contrast media alter immune responses in pro-inflammatory states. 2010, 51 (6):635-40 Acta Radiol
    Journal
    Acta radiologica (Stockholm, Sweden : 1987)
    URI
    http://hdl.handle.net/10147/126507
    DOI
    10.3109/02841851.2010.481679
    PubMed ID
    20528648
    Abstract
    Hypertonic saline causes a transient elevation of blood osmolality and has been shown to alter cellular inflammatory responses in pro-inflammatory states. Intravascular administration of iodine contrast media also causes a transient elevation of blood osmolarity.
    To investigate the effect of iodine contrast media on leukocyte-endothelial interaction in vivo using intravital microscopy.
    Male Sprague-Dawley rats (n=36) were randomized into six groups and were treated with: saline, high osmolar contrast medium, low osmolar contrast medium, and endotoxin alone and in combination with the high and low osmolar contrast media. The effect on leukocyte-endothelial interaction in the post-mesenteric venules was observed using the technique of intravital microscopy. The sequence of leukocyte rolling velocity, leukocyte-endothelial cell adherence, and transmigration was recorded and analyzed at 10 min intervals to a maximum of 120 min.
    Endotoxin significantly decreased the rolling velocity and increased the adherence and transmigration of leukocytes in a time-dependent manner. Both types of iodine contrast media attenuated this pro-inflammatory response to endotoxin. This effect began between 60 and 70 min after the onset of the experiment.
    Hyperosmolar and lower osmolar iodine contrast media attenuate the pro-inflammatory leukocyte-endothelial response to endotoxin in vivo.
    Item Type
    Article
    Language
    en
    ISSN
    1600-0455
    ae974a485f413a2113503eed53cd6c53
    10.3109/02841851.2010.481679
    Scopus Count
    Collections
    Beaumont Hospital

    entitlement

    Related articles

    • Taurine attenuates LPS-induced rolling and adhesion in rat microcirculation.
    • Authors: Egan BM, Chen G, Kelly CJ, Bouchier-Hayes DJ
    • Issue date: 2001 Feb
    • Thermotolerance protects against endotoxin-mediated microvascular injury.
    • Authors: Chen G, Kelly C, Chen H, Leahy A, Bouchier-Hayes D
    • Issue date: 2001 Feb
    • An approach for studies of mediator-induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery.
    • Authors: Yamaki K, Lindbom L, Thorlacius H, Hedqvist P, Raud J
    • Issue date: 1998 Feb
    • Soluble P-selectin antagonist mediates rolling velocity and adhesion of leukocytes in acutely inflamed venules.
    • Authors: Eppihimer MJ, Schaub RG
    • Issue date: 2001 Feb
    • High-density lipoproteins (HDL) inhibit endotoxin-induced leukocyte adhesion on endothelial cells in rats: effect of the acute-phase HDL.
    • Authors: Thaveeratitham P, Khovidhunkit W, Patumraj S
    • Issue date: 2007
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.