• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • Beaumont Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4708
    UlsterS
    4708
    Connacht
    1603
    Munster
    48
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Contrast-induced nephrotoxicity: possible synergistic effect of stress hyperglycemia.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    O'Donnell, David H
    Moloney, Michael A
    Bouchier-Hayes, David J
    Lee, Michael J
    Affiliation
    Department of Radiology and Vascular Surgery, Beaumont Hospital, The Royal College of Surgeons in Ireland, Dublin, Ireland. davidhodonnell@hotmail.com <davidhodonnell@hotmail.com>
    Issue Date
    2010-07
    MeSH
    Acetylcysteine
    Analysis of Variance
    Animals
    Apoptosis
    Contrast Media
    Dogs
    Hyperglycemia
    Kidney Diseases
    Kidney Tubules
    Necrosis
    Osmolar Concentration
    Oxidative Stress
    Taurine
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Contrast-induced nephrotoxicity: possible synergistic effect of stress hyperglycemia. 2010, 195 (1):W45-9 AJR Am J Roentgenol
    Journal
    AJR. American journal of roentgenology
    URI
    http://hdl.handle.net/10147/126506
    DOI
    10.2214/AJR.09.2847
    PubMed ID
    20566779
    Abstract
    Oxidative stress on the renal tubules has been implicated as a mechanism of injury in both stress hyperglycemia and contrast-induced nephrotoxicity. The purpose of this study was to determine whether the combination of these effects has a synergistic effect on accentuating renal tubular apoptosis and therefore increasing the risk of contrast-induced nephrotoxicity.
    Dog kidney cells were incubated with 5- and 30-mmol/L glucose solutions and no glucose and then exposed for 2 hours to three types of contrast media-high osmolar (370 mg I/mL), low osmolar (300 mg I/mL), and isoosmolar (320 mg I/mL)-and a mannitol control solution. In an identical experiment, each group of cells was pretreated with an antioxidant-N-acetylcysteine or taurine-to evaluate the protective effect, if any. Apoptosis was assessed with fluorescence-activated cell sorter flow cytometry.
    The high-osmolar contrast medium was associated with significantly elevated levels of apoptosis compared with the mannitol control (percentage apoptosis, 27.98 +/- 1.08 vs 6.19 +/- 0.771; p < 0.001). This effect was less pronounced after incubation with the low-osmolar agent but was still significant (percentage apoptosis, 20.19 +/- 0.3665 vs 6.19 +/- 0.771; p < 0.001). The isosmolar agent did not have a significant effect. Both the high- and low-osmolar contrast media coupled with hyperglycemia (30-mmol/L glucose) were associated with a significantly increased level of apoptosis. In all contrast medium groups, taurine had a greater protective effect on attenuation of cell apoptosis than did N-acetylcysteine.
    The combination of contrast medium and an elevated glucose level has a synergistic effect on apoptosis. Taurine may be a more effective prophylactic antioxidant than the currently advocated antioxidant, N-acetylcysteine.
    Item Type
    Article
    Language
    en
    ISSN
    1546-3141
    ae974a485f413a2113503eed53cd6c53
    10.2214/AJR.09.2847
    Scopus Count
    Collections
    Beaumont Hospital

    entitlement

    Related articles

    • Radiocontrast-induced renal tubular cell apoptosis: hypertonic versus oxidative stress.
    • Authors: Hizoh I, Haller C
    • Issue date: 2002 Aug
    • The protective role of telmisartan against nephrotoxicity induced by X-ray contrast media in rat model.
    • Authors: Duan SB, Wang YH, Liu FY, Xu XQ, Wang P, Zou Q, Peng YM
    • Issue date: 2009 Sep
    • N-acetylcysteine and taurine prevent hyperglycemia-induced insulin resistance in vivo: possible role of oxidative stress.
    • Authors: Haber CA, Lam TK, Yu Z, Gupta N, Goh T, Bogdanovic E, Giacca A, Fantus IG
    • Issue date: 2003 Oct
    • Comparative cytotoxicity of high-osmolar and low-osmolar contrast media on HKCs in vitro.
    • Authors: Duan S, Zhou X, Liu F, Peng Y, Chen Y, Pei Y, Ling G, Zhou L, Li Y, Pi Y, Tang K, Liu R, Li G
    • Issue date: 2006 Nov-Dec
    • Taurine prevents apoptosis induced by high ambient glucose in human tubule renal cells.
    • Authors: Verzola D, Bertolotto MB, Villaggio B, Ottonello L, Dallegri F, Frumento G, Berruti V, Gandolfo MT, Garibotto G, Deferran G
    • Issue date: 2002 Nov
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.