Affiliation
Department of Neuropathology, Beaumont Hospital, Dublin, UK.Issue Date
2010-05MeSH
Cervical VertebraeFemale
Hodgkin Disease
Humans
Spinal Canal
Spinal Cord Neoplasms
Spinal Neoplasms
Young Adult
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20 year old lady with a paraspinal mass. 2010, 20 (3):683-4 Brain Pathol.Journal
Brain pathology (Zurich, Switzerland)DOI
10.1111/j.1750-3639.2010.00382.xPubMed ID
20522095Abstract
A 20 year old female presented with a 4 month history of right upper limb pain and paraesthesias. She had no systemic symptoms and no prior medical or family history of note. MRI revealed a right-sided intradural extramedullary mass extending from C7-T1 and displacing the spinal cord. While awaiting surgery her symptoms progressed to involve the right lower limb. She was re-imaged and the lesion now extended from C5 to T3 with spinal cord compression at C7-T1. The radiological features and recent rapid growth were felt to be in keeping with a large plexiform neurofibroma. The patient underwent emergency resection of the lesion and pathology revealed Hodgkin's Lymphoma (HL)-mixed cellularity type. A mediastinal mass was identified on further imaging and biopsy confirmed the diagnosis of HL-stage IV. The patient is currently undergoing treatment with ABVD chemotherapy. CNS-HL is extremely rare and may occur de novo or in association with systemic disease. Lesions may be parenchymal or dural based and are usually intracranial with an increased risk of CNS involvement in HL-mixed-cellularity type as in our patient. This is the first report in the literature of CNS-HL radiologically mimicking a paraspinal plexiform neurofibroma.Item Type
ArticleLanguage
enISSN
1750-3639ae974a485f413a2113503eed53cd6c53
10.1111/j.1750-3639.2010.00382.x