The impact of peritransplant warfarin use on renal transplant outcome.
Authors
Connaughton, Dervla MPhelan, Paul J
Scheult, Jansen
Ma'ayeh, Marwan
O'Kelly, Patrick
Walshe, Joseph J
Magee, Colm
Little, Dilly
Hickey, David
Slaby, Jiri
Conlon, Peter J
Affiliation
Department of Nephrology, Beaumont Hospital, Dublin, Ireland.Issue Date
2011-03-31T09:36:07ZMeSH
AdultAnticoagulants
Female
Hemoglobins
Humans
Kidney Transplantation
Male
Middle Aged
Retrospective Studies
Transplantation, Homologous
Treatment Outcome
Warfarin
Metadata
Show full item recordCitation
The impact of peritransplant warfarin use on renal transplant outcome., 23 (5):587-92 J. Nephrol.Journal
Journal of nephrologyPubMed ID
20540039Additional Links
http://www.jnephrol.com/public/JN/Article/Article.aspx?UidArticle=FAD65BCB-4BFE-4672-95F9-24D196CFAFAEAbstract
The unplanned nature of kidney transplantation necessitates that patients undergo surgery without prior cessation of warfarin. Our study analyses the impact of warfarin treatment in the peritransplant period on graft outcome and perioperative transfusion requirements.We identified 31 patients undergoing deceased donor kidney transplantation who were concurrently receiving warfarin therapy, between 2000 and 2008. A random, sex-matched, adult, deceased donor control group of 62 patients was generated from the Irish transplant database.
The warfarin group were older (mean 47.5 vs. 42.5 years, p=0.067) and had spent longer on dialysis prior to transplantation (mean 3.5 vs. 2.1 years, p=0.004). Graft survival in the warfarin group was not significantly different at 1-, 3- and 5-year follow-ups. There was no statistically significant difference in red blood cell transfusions between the groups (45% vs. 29%, p=0.2). Warfarin patients had a prolonged mean cold ischaemia time (22.3 vs. 18.5 hours, p=0.002).
This study demonstrates excellent short- and long-term results for kidney transplantation in patients requiring warfarin at the time of transplantation.
Item Type
ArticleLanguage
enISSN
1121-8428Collections
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