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    The impact of peritransplant warfarin use on renal transplant outcome.

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    Authors
    Connaughton, Dervla M
    Phelan, Paul J
    Scheult, Jansen
    Ma'ayeh, Marwan
    O'Kelly, Patrick
    Walshe, Joseph J
    Magee, Colm
    Little, Dilly
    Hickey, David
    Slaby, Jiri
    Conlon, Peter J
    Show allShow less
    Affiliation
    Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
    Issue Date
    2011-03-31T09:36:07Z
    MeSH
    Adult
    Anticoagulants
    Female
    Hemoglobins
    Humans
    Kidney Transplantation
    Male
    Middle Aged
    Retrospective Studies
    Transplantation, Homologous
    Treatment Outcome
    Warfarin
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    Citation
    The impact of peritransplant warfarin use on renal transplant outcome., 23 (5):587-92 J. Nephrol.
    Journal
    Journal of nephrology
    URI
    http://hdl.handle.net/10147/126493
    PubMed ID
    20540039
    Additional Links
    http://www.jnephrol.com/public/JN/Article/Article.aspx?UidArticle=FAD65BCB-4BFE-4672-95F9-24D196CFAFAE
    Abstract
    The unplanned nature of kidney transplantation necessitates that patients undergo surgery without prior cessation of warfarin. Our study analyses the impact of warfarin treatment in the peritransplant period on graft outcome and perioperative transfusion requirements.
    We identified 31 patients undergoing deceased donor kidney transplantation who were concurrently receiving warfarin therapy, between 2000 and 2008. A random, sex-matched, adult, deceased donor control group of 62 patients was generated from the Irish transplant database.
    The warfarin group were older (mean 47.5 vs. 42.5 years, p=0.067) and had spent longer on dialysis prior to transplantation (mean 3.5 vs. 2.1 years, p=0.004). Graft survival in the warfarin group was not significantly different at 1-, 3- and 5-year follow-ups. There was no statistically significant difference in red blood cell transfusions between the groups (45% vs. 29%, p=0.2). Warfarin patients had a prolonged mean cold ischaemia time (22.3 vs. 18.5 hours, p=0.002).
    This study demonstrates excellent short- and long-term results for kidney transplantation in patients requiring warfarin at the time of transplantation.
    Item Type
    Article
    Language
    en
    ISSN
    1121-8428
    Collections
    Beaumont Hospital

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