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dc.contributor.authorBurns, K
dc.contributor.authorMorris-Downes, M
dc.contributor.authorFawley, W N
dc.contributor.authorSmyth, E
dc.contributor.authorWilcox, M H
dc.contributor.authorFitzpatrick, F
dc.date.accessioned2011-03-31T08:47:02Z
dc.date.available2011-03-31T08:47:02Z
dc.date.issued2010-08
dc.identifier.citationInfection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland. 2010, 75 (4):287-91 J. Hosp. Infect.en
dc.identifier.issn1532-2939
dc.identifier.pmid20621236
dc.identifier.doi10.1016/j.jhin.2010.03.025
dc.identifier.urihttp://hdl.handle.net/10147/126473
dc.description.abstractClostridium difficile is an important healthcare-associated pathogen. Hypervirulent strains such as those belonging to ribotype 027 have been widely reported in recent years. A second strain associated with hypervirulence is ribotype 078 and the prevalence of Clostridium difficile infection (CDI) due to this ribotype appears to be increasing. This report describes an outbreak, in which 15cases of CDI due to ribotype 078 were detected in an Irish hospital and from a nursing home in the hospital's catchment area. C. difficile ribotype 078 accounted for 15% of total isolates submitted for ribotyping. The average age of patients with CDI due to ribotype 078 was 76 years. Forty-six percent of patients experienced recurrence of symptoms within eight weeks of diagnosis and CDI was felt to have directly contributed to five of the eight deaths. Use of enhanced DNA fingerprinting identified clusters within the 15 cases and suggested hitherto unrecognised links between some patients with CDI. Such approaches offer the promise to delineate common sources and transmission routes for C. difficile.
dc.language.isoenen
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshClostridium Infections
dc.subject.meshClostridium difficile
dc.subject.meshCross Infection
dc.subject.meshDNA Fingerprinting
dc.subject.meshDisease Outbreaks
dc.subject.meshFeces
dc.subject.meshFemale
dc.subject.meshHospital Mortality
dc.subject.meshHumans
dc.subject.meshIreland
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNursing Homes
dc.subject.meshPrevalence
dc.subject.meshRecurrence
dc.subject.meshRibotyping
dc.titleInfection due to C. difficile ribotype 078: first report of cases in the Republic of Ireland.en
dc.typeArticleen
dc.contributor.departmentDepartment of Clinical Microbiology, Beaumont Hospital, Dublin 9, Ireland. burnskaren@yahoo.co.uken
dc.identifier.journalThe Journal of hospital infectionen
dc.description.provinceLeinster
html.description.abstractClostridium difficile is an important healthcare-associated pathogen. Hypervirulent strains such as those belonging to ribotype 027 have been widely reported in recent years. A second strain associated with hypervirulence is ribotype 078 and the prevalence of Clostridium difficile infection (CDI) due to this ribotype appears to be increasing. This report describes an outbreak, in which 15cases of CDI due to ribotype 078 were detected in an Irish hospital and from a nursing home in the hospital's catchment area. C. difficile ribotype 078 accounted for 15% of total isolates submitted for ribotyping. The average age of patients with CDI due to ribotype 078 was 76 years. Forty-six percent of patients experienced recurrence of symptoms within eight weeks of diagnosis and CDI was felt to have directly contributed to five of the eight deaths. Use of enhanced DNA fingerprinting identified clusters within the 15 cases and suggested hitherto unrecognised links between some patients with CDI. Such approaches offer the promise to delineate common sources and transmission routes for C. difficile.


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