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    Osteoprotegerin and biomarkers of vascular inflammation in type 2 diabetes.

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    Authors
    O'Sullivan, Eoin P
    Ashley, David T
    Davenport, Colin
    Devlin, Niamh
    Crowley, Rachel
    Agha, Amar
    Thompson, Christopher J
    O'Gorman, Donal
    Smith, Diarmuid
    Affiliation
    Department of Diabetes, Royal College of Surgeons in Ireland Medical School, Beaumont Hospital, Dublin, Ireland.
    Issue Date
    2010-09
    MeSH
    Biological Markers
    C-Reactive Protein
    Diabetes Mellitus, Type 2
    Diabetic Angiopathies
    Female
    Humans
    Inflammation
    Interleukin-6
    Male
    Middle Aged
    Osteoprotegerin
    RANK Ligand
    TNF-Related Apoptosis-Inducing Ligand
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    Citation
    Osteoprotegerin and biomarkers of vascular inflammation in type 2 diabetes. 2010, 26 (6):496-502 Diabetes Metab. Res. Rev.
    Journal
    Diabetes/metabolism research and reviews
    URI
    http://hdl.handle.net/10147/126465
    DOI
    10.1002/dmrr.1109
    PubMed ID
    20809534
    Abstract
    Osteoprotegerin (OPG), receptor activator for nuclear factor kappa beta ligand (RANKL) and tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) are newly discovered members of the tumour necrosis factor-alpha receptor superfamily. While their role in bone metabolism is well described, their function within the vasculature is poorly understood. OPG inhibits vascular calcification in vitro and high serum levels have been demonstrated in type 2 diabetes, but serum RANKL and TRAIL and their potential correlation with well-established biomarkers of subclinical vascular inflammation such as high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) have not been described.
    Sixty-two patients with well-controlled type 2 diabetes and an age, gender and body mass index-matched group of 58 healthy individuals were recruited. Serum OPG, RANKL and TRAIL were measured using commercial enzyme-linked immunosorbent assays, as were hsCRP and IL-6.
    Serum OPG, IL-6 and hsCRP levels, but not RANKL or TRAIL, were higher in patients with type 2 diabetes mellitus than in healthy controls, after adjustment for age and gender. After exclusion of diabetes patients with a history of micro- or macrovascular disease, OPG remained significantly higher in those with diabetes, but IL-6 and hsCRP levels were no longer elevated. There was a positive correlation between OPG and IL-6 in the group as a whole, but no correlation was found between RANKL or TRAIL and either hsCRP or IL-6.
    OPG, but not RANKL or TRAIL, is significantly increased in type 2 diabetes. Higher OPG (but not IL-6 or hsCRP) in those without vascular disease suggests these biomarkers reflect separate pathophysiological processes in the vasculature.
    Item Type
    Article
    Language
    en
    ISSN
    1520-7560
    ae974a485f413a2113503eed53cd6c53
    10.1002/dmrr.1109
    Scopus Count
    Collections
    Beaumont Hospital

    entitlement

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