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    Comparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting.

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    Authors
    Moloney, M A
    McHugh, S
    O' Donnell, D H
    Casey, R G
    Kavanagh, E G
    Grace, P A
    Fitzgerald, P
    Bouchier-Hayes, D J
    Affiliation
    Department of Vascular Surgery, Beaumont Hospital, Beaumont Road, Beaumont, Dublin 9, Ireland, tmoloney90@hotmail.com.
    Issue Date
    2010-11-11
    
    Metadata
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    Citation
    Comparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting. 2010: Ir J Med Sci
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/126130
    DOI
    10.1007/s11845-010-0513-3
    PubMed ID
    21069574
    Abstract
    BACKGOUND: Abdominal aortic aneurysm (AAA) surgery provides a unique opportunity to study the impact of arterial stiffness on central haemodynamics, reflected in augmentation index (AI). The aneurysmal aorta is significantly stiffer than undilated age-matched aorta. AIM: We investigated whether replacement of an aneurysmal aorta with a compliant graft would result in a decrease in AI, which would thus decrease myocardial workload parameters. METHODS: Patients undergoing elective open or endovascular AAA repair were assessed with applanation tonometry and laser fluximetry pre-operatively, immediately and long-term post-operatively. RESULTS: Replacement of a small segment of abnormal conduit vessel resulted in improvements in AI, demonstrating that arterial stiffness can be surgically manipulated. CONCLUSIONS: These results reflect a decreased myocardial workload post-aortic grafting. This decrease in AI is important from a risk factor management perspective, and arterial stiffness should become a further recognised and screened for risk factor in patients with known aneurysmal disease.
    Item Type
    Article In Press
    ISSN
    1863-4362
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-010-0513-3
    Scopus Count
    Collections
    Beaumont Hospital

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