Comparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting.
Authors
Moloney, M AMcHugh, S
O' Donnell, D H
Casey, R G
Kavanagh, E G
Grace, P A
Fitzgerald, P
Bouchier-Hayes, D J
Affiliation
Department of Vascular Surgery, Beaumont Hospital, Beaumont Road, Beaumont, Dublin 9, Ireland, tmoloney90@hotmail.com.Issue Date
2010-11-11
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Comparison of arterial stiffness and microcirculatory changes following abdominal aortic aneurysm grafting. 2010: Ir J Med SciJournal
Irish journal of medical scienceDOI
10.1007/s11845-010-0513-3PubMed ID
21069574Abstract
BACKGOUND: Abdominal aortic aneurysm (AAA) surgery provides a unique opportunity to study the impact of arterial stiffness on central haemodynamics, reflected in augmentation index (AI). The aneurysmal aorta is significantly stiffer than undilated age-matched aorta. AIM: We investigated whether replacement of an aneurysmal aorta with a compliant graft would result in a decrease in AI, which would thus decrease myocardial workload parameters. METHODS: Patients undergoing elective open or endovascular AAA repair were assessed with applanation tonometry and laser fluximetry pre-operatively, immediately and long-term post-operatively. RESULTS: Replacement of a small segment of abnormal conduit vessel resulted in improvements in AI, demonstrating that arterial stiffness can be surgically manipulated. CONCLUSIONS: These results reflect a decreased myocardial workload post-aortic grafting. This decrease in AI is important from a risk factor management perspective, and arterial stiffness should become a further recognised and screened for risk factor in patients with known aneurysmal disease.Item Type
Article In PressISSN
1863-4362ae974a485f413a2113503eed53cd6c53
10.1007/s11845-010-0513-3
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