AffiliationHRB Clinician Scientist, Trinity College and Beaumont Hospital, Dublin, Ireland, firstname.lastname@example.org.
MetadataShow full item record
CitationManagement of respiratory symptoms in ALS. 2011, 258 (3):359-65 J. Neurol.
JournalJournal of neurology
AbstractRespiratory insufficiency is a frequent feature of ALS and is present in almost all cases at some stage of the illness. It is the commonest cause of death in ALS. FVC is used as important endpoint in many clinical trials, and in decision-making events for patients with ALS, although there are limitations to its predictive utility. There are multiple causes of respiratory muscle failure, all of which act to produce a progressive decline in pulmonary function. Diaphragmatic fatigue and weakness, coupled with respiratory muscle weakness, lead to reduced lung compliance and atelectasis. Increased secretions increase the risk of aspiration pneumonia, which further compromises respiratory function. Bulbar dysfunction can lead to nutritional deficiency, which in turn increases the fatigue of respiratory muscles. Early recognition of respiratory decline and symptomatic intervention, including non-invasive ventilation can significantly enhance both quality of life and life expectancy in ALS. Patients with respiratory failure should be advised to consider an advance directive to avoid emergency mechanical ventilation.
- Amyotrophic lateral sclerosis: evaluation and treatment of respiratory impairment.
- Authors: Lechtzin N, Rothstein J, Clawson L, Diette GB, Wiener CM
- Issue date: 2002 Mar
- [Ventilatory Support and Management of Secretions in Amyotrophic Lateral Sclerosis].
- Authors: Boentert M, Young P
- Issue date: 2016 Oct
- Symptomatic treatment of respiratory and nutritional failure in amyotrophic lateral sclerosis.
- Authors: Hardiman O
- Issue date: 2000 Apr
- Expiratory muscle weakness and assisted cough in ALS.
- Authors: Lahrmann H, Wild M, Zdrahal F, Grisold W
- Issue date: 2003 Apr
- Review of respiratory care of the patient with amyotrophic lateral sclerosis.
- Authors: Sherman MS, Paz HL
- Issue date: 1994