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dc.contributor.authorGriffin, Alison
dc.contributor.authorO'Shea, Paula
dc.contributor.authorFitzGerald, Roland
dc.contributor.authorO'Connor, Gerard
dc.contributor.authorTormey, William
dc.date.accessioned2011-03-29T14:25:36Z
dc.date.available2011-03-29T14:25:36Z
dc.date.issued2011-01
dc.identifier.citationEstablishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines. 2011, 48 (Pt 1):41-4 Ann. Clin. Biochem.en
dc.identifier.issn1758-1001
dc.identifier.pmid21123298
dc.identifier.doi10.1258/acb.2010.010062
dc.identifier.urihttp://hdl.handle.net/10147/126126
dc.description.abstractNormetanephrine and metanephrine are intermediate metabolites of noradrenaline and adrenaline metabolism. To assess whether normetanephrine and metanephrine analysis may aid in the diagnosis of Neuroblastoma, a reference interval for these metabolites must first be established.
dc.description.abstractThe overall aim of this study was to establish a paediatric age-related reference interval for the measurement of total fractionated metanephrines.
dc.description.abstractA total of 267 urine samples were analysed following acid hydrolysis. This releases the metanephrines from their sulphate-bound metabolites. The samples were analysed using reverse phase high-performance liquid chromatography with electro-chemical detection on a Gilson automated sequential trace enrichment of dialysate sample system.
dc.description.abstractData were analysed using Minitab Release version 14. Outliers were removed using the Dixon/Reed one-third rule. Partitioning of the age groups was achieved using Harris and Boyd's standard normal deviate test. Non-parametric analysis of the data was performed, followed by the establishment of the 2.5th and the 97.5th reference limits.
dc.description.abstractThe established reference intervals are described in Table 2.
dc.language.isoenen
dc.titleEstablishment of a paediatric age-related reference interval for the measurement of urinary total fractionated metanephrines.en
dc.typeArticleen
dc.contributor.departmentDepartment of Chemical Pathology, Beaumont Hospital, Dublin 9, Ireland. alisongriffin@beaumont.ieen
dc.identifier.journalAnnals of clinical biochemistryen
dc.description.provinceLeinster
html.description.abstractNormetanephrine and metanephrine are intermediate metabolites of noradrenaline and adrenaline metabolism. To assess whether normetanephrine and metanephrine analysis may aid in the diagnosis of Neuroblastoma, a reference interval for these metabolites must first be established.
html.description.abstractThe overall aim of this study was to establish a paediatric age-related reference interval for the measurement of total fractionated metanephrines.
html.description.abstractA total of 267 urine samples were analysed following acid hydrolysis. This releases the metanephrines from their sulphate-bound metabolites. The samples were analysed using reverse phase high-performance liquid chromatography with electro-chemical detection on a Gilson automated sequential trace enrichment of dialysate sample system.
html.description.abstractData were analysed using Minitab Release version 14. Outliers were removed using the Dixon/Reed one-third rule. Partitioning of the age groups was achieved using Harris and Boyd's standard normal deviate test. Non-parametric analysis of the data was performed, followed by the establishment of the 2.5th and the 97.5th reference limits.
html.description.abstractThe established reference intervals are described in Table 2.


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