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dc.contributor.authorSundram, Frederick
dc.contributor.authorCannon, Mary
dc.contributor.authorDoherty, Colin P
dc.contributor.authorBarker, Gareth J
dc.contributor.authorFitzsimons, Mary
dc.contributor.authorDelanty, Norman
dc.contributor.authorCotter, David
dc.date.accessioned2011-03-29T14:39:55Z
dc.date.available2011-03-29T14:39:55Z
dc.date.issued2010-12
dc.identifier.citationNeuroanatomical correlates of psychosis in temporal lobe epilepsy: voxel-based morphometry study. 2010, 197:482-92 Br J Psychiatryen
dc.identifier.issn1472-1465
dc.identifier.pmid21119155
dc.identifier.doi10.1192/bjp.bp.110.080218
dc.identifier.urihttp://hdl.handle.net/10147/126115
dc.description.abstractTemporal lobe epilepsy is associated with a significant risk of psychosis but there are only limited studies investigating the underlying neurobiology.
dc.description.abstractTo characterise neuroanatomical changes in temporal lobe epilepsy and comorbid psychosis.
dc.description.abstractThe study population comprised all individuals with temporal lobe epilepsy on the epilepsy database at the National Centre for Epilepsy and Epilepsy Neurosurgery in Ireland (Beaumont Hospital) between 2002 and 2006. Ten people with temporal lobe epilepsy with psychosis were matched for age, gender, handedness, epilepsy duration, seizure laterality, severity of epilepsy and anti-epileptic medication with ten comparison participants with temporal lobe epilepsy only. Participants received a magnetic resonance imaging scan and voxel-based morphometry analyses were applied to grey and white matter anatomy.
dc.description.abstractSignificant grey matter reduction was found bilaterally in those with temporal lobe epilepsy with psychosis in the temporal lobes in the inferior, middle and superior temporal gyri and fusiform gyri, and unilaterally in the left parahippocampal gyrus and hippocampus. Significant extratemporal grey matter reduction was found bilaterally in the insula, cerebellum, caudate nuclei and in the right cingulum and left inferior parietal lobule. Significant white matter reduction in those with temporal lobe epilepsy with psychosis was found bilaterally in the hippocampus, parahippocampal/fusiform gyri, middle/inferior temporal gyri, cingulum, corpus callosum, posterior thalamic radiation, anterior limb of internal capsule and white matter fibres from the caudate nuclei, and unilaterally in the left lingual gyrus and right midbrain and superior temporal gyrus.
dc.description.abstractSignificant grey and white matter deficits occur in temporal lobe epilepsy with psychosis. These encompass the medial temporal lobe structures but also extend to lateral temporal and extratemporal regions. Some of these deficits overlap with those found in schizophrenia.
dc.language.isoenen
dc.titleNeuroanatomical correlates of psychosis in temporal lobe epilepsy: voxel-based morphometry study.en
dc.typeArticleen
dc.contributor.departmentDepartment of Psychiatry, Education and Research Centre, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland. fsundram@rcsi.ieen
dc.identifier.journalThe British journal of psychiatry : the journal of mental scienceen
dc.description.provinceLeinster
html.description.abstractTemporal lobe epilepsy is associated with a significant risk of psychosis but there are only limited studies investigating the underlying neurobiology.
html.description.abstractTo characterise neuroanatomical changes in temporal lobe epilepsy and comorbid psychosis.
html.description.abstractThe study population comprised all individuals with temporal lobe epilepsy on the epilepsy database at the National Centre for Epilepsy and Epilepsy Neurosurgery in Ireland (Beaumont Hospital) between 2002 and 2006. Ten people with temporal lobe epilepsy with psychosis were matched for age, gender, handedness, epilepsy duration, seizure laterality, severity of epilepsy and anti-epileptic medication with ten comparison participants with temporal lobe epilepsy only. Participants received a magnetic resonance imaging scan and voxel-based morphometry analyses were applied to grey and white matter anatomy.
html.description.abstractSignificant grey matter reduction was found bilaterally in those with temporal lobe epilepsy with psychosis in the temporal lobes in the inferior, middle and superior temporal gyri and fusiform gyri, and unilaterally in the left parahippocampal gyrus and hippocampus. Significant extratemporal grey matter reduction was found bilaterally in the insula, cerebellum, caudate nuclei and in the right cingulum and left inferior parietal lobule. Significant white matter reduction in those with temporal lobe epilepsy with psychosis was found bilaterally in the hippocampus, parahippocampal/fusiform gyri, middle/inferior temporal gyri, cingulum, corpus callosum, posterior thalamic radiation, anterior limb of internal capsule and white matter fibres from the caudate nuclei, and unilaterally in the left lingual gyrus and right midbrain and superior temporal gyrus.
html.description.abstractSignificant grey and white matter deficits occur in temporal lobe epilepsy with psychosis. These encompass the medial temporal lobe structures but also extend to lateral temporal and extratemporal regions. Some of these deficits overlap with those found in schizophrenia.


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