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    Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours.

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    Authors
    Caiazza, F
    McCarthy, N S
    Young, L
    Hill, A D K
    Harvey, B J
    Thomas, W
    Affiliation
    Department of Molecular Medicine, Royal College of Surgeons in Ireland, Education and Research Centre, Beaumont Hospital, Dublin 9, Ireland.
    Issue Date
    2011-01-18
    MeSH
    Antineoplastic Agents, Hormonal
    Breast Neoplasms
    Cohort Studies
    Cytosol
    Female
    Humans
    Oligonucleotide Array Sequence Analysis
    Phospholipases A2
    Prognosis
    RNA, Messenger
    Receptor, Epidermal Growth Factor
    Reverse Transcriptase Polymerase Chain Reaction
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    Citation
    Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours. 2011, 104 (2):338-44 Br. J. Cancer
    Journal
    British journal of cancer
    URI
    http://hdl.handle.net/10147/126114
    DOI
    10.1038/sj.bjc.6606025
    PubMed ID
    21119660
    Additional Links
    http://www.nature.com/bjc/journal/v104/n2/pdf/6606025a.pdf
    Abstract
    The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression correlated with EGFR/HER2 over-expression in a small number of breast cancer cell lines.
    The importance of differential cPLA(2)α activity in clinical breast cancer was established by relating the expression of cPLA(2)α in tissue samples from breast cancer patients, and two microarray-based gene expression datasets to different clinicopathological and therapeutic parameters.
    High cPLA(2)α mRNA expression correlated with clinical parameters of poor prognosis, which are characteristic of highly invasive tumours of the HER2-positive and basal-like subtype, including low oestrogen receptor expression and high EGFR expression. High cPLA(2)α expression decreased overall survival in patients with luminal cancers, and correlated with a reduced effect of tamoxifen treatment. The cPLA(2)α expression was an independent predictive parameter of poor response to endocrine therapy in the first 5 years of follow-up.
    This study shows a role of cPLA(2)α in luminal breast cancer progression, in which the enzyme could represent a novel therapeutic target and a predictive marker.
    Item Type
    Article
    Language
    en
    ISSN
    1532-1827
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6606025
    Scopus Count
    Collections
    Beaumont Hospital

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