In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase.

Authors
Desgranges, Stephane
Le Prieult, Florie
Daly, Alan
Lydon, Jennifer
Brennan, Marian
Rai, Dilip K
Subasinghage, Anusha P
Hewage, Chandralal M
Cryan, Sally-Ann
Greene, Catherine
Affiliation
Centre for Synthesis and Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin 9; Department of Microbiology, Beaumont Hospital, Dublin 9; Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, Conway Institute, University College Dublin, Belfield, Dublin 4; School of Pharmacy, Royal College of Surgeons in Ireland, 123, St. Stephen's Green, Dublin 2; Department of Respiratory Research, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin 9; and Department of Chemical & Environmental Sciences, University of Limerick, Ireland.
Issue Date
2011-02-22

Metadata
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Citation
In Vitro Activities against Cystic Fibrosis Pathogens of Synthetic Host Defence Propeptides Processed by Neutrophil Elastase. 2011:notAntimicrob Agents Chemother
Journal
Antimicrobial agents and chemotherapy
URI
http://hdl.handle.net/10147/126091
DOI
10.1128/AAC.01384-10
PubMed ID
21343449
Additional Links
http://aac.asm.org/cgi/reprint/AAC.01384-10v1?view=long&pmid=21343449
Abstract
The antimicrobial and haemolytic activities of a host defence peptide can be controlled by modification as a propeptide of reduced net charge which can be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.
Item Type
Article in Press
Language
null
ISSN
1098-6596
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