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    Characterization of a Novel Arginine Catabolic Mobile Element (ACME) and Staphylococcal Chromosomal Cassette mec Composite Island with Significant Homology to Staphylococcus epidermidis ACME type II in Methicillin-Resistant Staphylococcus aureus Genotype ST22-MRSA-IV.

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    Authors
    Shore, Anna C
    Rossney, Angela S
    Brennan, Orla M
    Kinnevey, Peter M
    Humphreys, Hilary
    Sullivan, Derek J
    Goering, Richard V
    Ehricht, Ralf
    Monecke, Stefan
    Coleman, David C
    Affiliation
    Microbiology Research Unit, Dublin Dental University Hospital, University of Dublin, Trinity College Dublin, Ireland; National MRSA Reference Laboratory, Dublin, Ireland; Department of Clinical Microbiology, The Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Microbiology, Beaumont Hospital, Dublin, Ireland; Creighton University, Omaha, Nebraska, USA; Alere Technologies GmbH, Jena, Germany; Institute for Medical Microbiology and Hygiene, Faculty of Medicine "Carl Gustav Carus", Technical University of Dresden, Germany.
    Issue Date
    2011-02-22
    
    Metadata
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    Citation
    Characterization of a Novel Arginine Catabolic Mobile Element (ACME) and Staphylococcal Chromosomal Cassette mec Composite Island with Significant Homology to Staphylococcus epidermidis ACME type II in Methicillin-Resistant Staphylococcus aureus Genotype ST22-MRSA-IV. 2011:notAntimicrob Agents Chemother
    Journal
    Antimicrobial agents and chemotherapy
    URI
    http://hdl.handle.net/10147/126075
    DOI
    10.1128/AAC.01756-10
    PubMed ID
    21343442
    Additional Links
    http://aac.asm.org/cgi/reprint/AAC.01756-10v1?view=long&pmid=21343442
    Abstract
    The arginine catabolic mobile element (ACME) is prevalent among ST8-MRSA-IVa (USA300) isolates and evidence suggests that ACME enhances the ability of ST8-MRSA-IVa to grow and survive on its host. ACME has been identified in a small number of isolates belonging to other MRSA clones but is widespread among coagulase-negative staphylococci (CoNS). This study reports the first description of ACME in two distinct strains of the pandemic ST22-MRSA-IV clone. A total of 238 MRSA isolates recovered in Ireland between 1971 and 2008 were investigated for ACME using a DNA microarray. Twenty-three isolates (9.7%) were ACME-positive, all were either MRSA genotype ST8-MRSA-IVa (7/23, 30%) or ST22-MRSA-IV (16/23, 70%). Whole-genome sequencing and comprehensive molecular characterization revealed the presence of a novel 46-kb ACME and SCCmec composite island (ACME/SCCmec-CI) in ST22-MRSA-IVh isolates (n = 15). This ACME/SCCmec-CI consists of a 12-kb DNA region previously identified in ACME type II in S. epidermidis ATCC 12228, a truncated copy of the J1 region of SCCmec I and a complete SCCmec IVh element. The composite island has a novel genetic organization with ACME located within orfX and SCCmec located downstream of ACME. One pvl-positive ST22-MRSA-IVa isolate carried ACME located downstream of SCCmec IVa as previously described in ST8-MRSA-IVa. These results suggest that ACME has been acquired by ST22-MRSA-IV on two independent occasions. At least one of these instances may have involved horizontal transfer and recombination events between MRSA and CoNS. The presence of ACME may enhance dissemination of ST22-MRSA-IV, an already successful MRSA clone.
    Item Type
    Article in Press
    Language
    null
    ISSN
    1098-6596
    ae974a485f413a2113503eed53cd6c53
    10.1128/AAC.01756-10
    Scopus Count
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    Beaumont Hospital

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