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    Metronidazole-induced pancreatitis.

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    Authors
    O'Halloran, E
    Hogan, A
    Mealy, K
    Affiliation
    Department of Surgery, Wexford General Hospital, Wexford, Ireland. ohalloranemily@gmail.com
    Issue Date
    2010
    MeSH
    Adult
    Anti-Infective Agents
    Female
    Humans
    Metronidazole
    Pancreatitis
    Treatment Outcome
    
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    Citation
    Metronidazole-induced pancreatitis. 2010, 2010:523468 HPB Surg
    Journal
    HPB surgery : a world journal of hepatic, pancreatic and biliary surgery
    URI
    http://hdl.handle.net/10147/125832
    DOI
    10.1155/2010/523468
    PubMed ID
    20862338
    Abstract
    A 25-year-old caucasian lady presented to the Accident & Emergency department complaining of acute onset severe epigastric pain radiating through to the back with associated nausea and vomiting. A diagnosis of acute pancreatitis was made. Symptoms commenced after the third dose of Metronidazole therapy prescribed for a recurrent periodontal abscess. The patient described a similar episode 10 months previously. On neither occasion were any other medications being taken, there was no history of alcohol abuse and no other gastro-intestinal aetiology could be identified on imaging. Symptoms resolved quickly upon discontinuation of the antibiotic agent. We conclude therefore that Metronidazole can reasonably be identified as the only potential causative agent.
    The proportion of cases of pancreatitis caused by drugs is estimated to be around 2% in the general population. The exact mechanism of action of Metronidazole induced pancreatitis is unclear but a trigger role for the drug seems likely.
    This case provides the eighth report of Metronidazole induced pancreatitis. All of the cases were reported in females and ran a benign course. Early diagnosis, discontinuation of the drug and supportive care will lead to a successful recovery in the majority of cases.
    Item Type
    Article
    Language
    en
    ISSN
    1607-8462
    ae974a485f413a2113503eed53cd6c53
    10.1155/2010/523468
    Scopus Count
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