Periodontitis and type 2 diabetes: is oxidative stress the mechanistic link?
AffiliationDept. of Restorative Dentistry, Cork University Dental School & Hospital, Cork, Ireland. email@example.com
MeSHDiabetes Mellitus, Type 2
MetadataShow full item record
CitationPeriodontitis and type 2 diabetes: is oxidative stress the mechanistic link? 2009, 54 (2):41-7 Scott Med J
JournalScottish medical journal
AbstractPeriodontitis is a common, chronic inflammatory disease initiated by bacteria which has an increased prevalence and severity in patients with type 2 diabetes. Recent studies indicate that the co-morbid presence of periodontitis can, in turn, adversely affect diabetic status and the treatment of periodontitis can lead to improved metabolic control in diabetes patients. Current evidence points to a bidirectional interrelationship between diabetes and inflammatory periodontitis. The importance of oxidative stress-inflammatory pathways in the pathogenesis of type 2 diabetes and periodontitis has recently received attention. Given the bidirectional relationship between these two conditions, this review discusses the potential synergistic interactions along the oxidative stress-inflammation axis common to both type 2 diabetes and periodontitis, and the implications of this relationship for diabetic patients.
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