• S. mutans exacerbates base-metal dental casting alloy toxicity

      McGinley E; Moran GP; Dowling AH; Fleming GJP (Journal of Dental Research, 2013)
    • Seating load parameters impact on dental ceramic reinforcement conferred by cementation with resin-cements.

      Addison, Owen; Sodhi, Amandeep; Fleming, Garry J P; Biomaterials Unit, University of Birmingham School of Dentistry, St. Chad's Queensway, Birmingham B4 6NN, UK. addisono@adf.bham.ac.uk (2010-09)
      The magnitude of resin-reinforcement conferred was sensitive to the loading parameters investigated although the mechanisms underlying the variation appear complex. Similar patterns of variability can be expected clinically impacting on the clinical longevity of resin-cemented glass-ceramic restorations.
    • A Ser29Leu substitution in the cytosine deaminase Fca1p is responsible for clade-specific flucytosine resistance in Candida dubliniensis.

      McManus, Brenda A; Moran, Gary P; Higgins, Judy A; Sullivan, Derek J; Coleman, David C; Microbiology Research Unit, Division of Oral Biosciences, School of Dental Science and Dublin Dental Hospital, University of Dublin, Trinity College Dublin, Dublin 2, Ireland. (2009-11)
      The population structure of the opportunistic yeast pathogen Candida dubliniensis is composed of three main multilocus sequence typing clades (clades C1 to C3), and clade C3 predominantly consists of isolates from the Middle East that exhibit high-level resistance (MIC(50) > or = 128 microg/ml) to the fungicidal agent flucytosine (5FC). The close relative of C. dubliniensis, C. albicans, also exhibits clade-specific resistance to 5FC, and resistance is most commonly mediated by an Arg101Cys substitution in the FUR1 gene encoding uracil phosphoribosyltransferase. Broth microdilution assays with fluorouracil (5FU), the toxic deaminated form of 5FC, showed that both 5FC-resistant and 5FC-susceptible C. dubliniensis isolates exhibited similar 5FU MICs, suggesting that the C. dubliniensis cytosine deaminase (Fca1p) encoded by C. dubliniensis FCA1 (CdFCA1) may play a role in mediating C. dubliniensis clade-specific 5FC resistance. Amino acid sequence analysis of the CdFCA1 open reading frame (ORF) identified a homozygous Ser29Leu substitution in all 12 5FC-resistant isolates investigated which was not present in any of the 9 5FC-susceptible isolates examined. The tetracycline-inducible expression of the CdFCA1 ORF from a 5FC-susceptible C. dubliniensis isolate in two separate 5FC-resistant clade C3 isolates restored susceptibility to 5FC, demonstrating that the Ser29Leu substitution was responsible for the clade-specific 5FC resistance and that the 5FC resistance encoded by FCA1 genes with the Ser29Leu transition is recessive. Quantitative real-time PCR analysis showed no significant difference in CdFCA1 expression between 5FC-susceptible and 5FC-resistant isolates in either the presence or the absence of subinhibitory concentrations of 5FC, suggesting that the Ser29Leu substitution in the CdFCA1 ORF is the sole cause of 5FC resistance in clade C3 C. dubliniensis isolates.
    • A sex-specific association between a 15q25 variant and upper aerodigestive tract cancers.

      Chen, Dan; Truong, Therese; Gaborieau, Valerie; Byrnes, Graham; Chabrier, Amelie; Chuang, Shu-chun; Olshan, Andrew F; Weissler, Mark C; Luo, Jingchun; Romkes, Marjorie; Buch, Shama; Nukui, Tomoko; Franceschi, Silvia; Herrero, Rolando; Talamini, Renato; Kelsey, Karl T; Christensen, Brock; McClean, Michael D; Lacko, Martin; Manni, Johannes J; Peters, Wilbert H M; Lubiński, Jan; Trubicka, Joanna; Lener, Marcin; Muscat, Joshua E; Lazarus, Philip; Wei, Qingyi; Sturgis, Erich M; Zhang, Zuo-Feng; Chang, Shen-Chih; Wang, Renyi; Schwartz, Stephen M; Chen, Chu; Benhamou, Simone; Lagiou, Pagona; Holcátová, Ivana; Richiardi, Lorenzo; Kjaerheim, Kristina; Agudo, Antonio; Castellsagué, Xavier; Macfarlane, Tatiana V; Barzan, Luigi; Canova, Cristina; Thakker, Nalin S; Conway, David I; Znaor, Ariana; Healy, Claire M; Ahrens, Wolfgang; Zaridze, David; Szeszenia-Dabrowska, Neonila; Lissowska, Jolanta; Fabianova, Eleonora; Bucur, Alexandru; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Curado, Maria Paula; Koifman, Sergio; Menezes, Ana; Wünsch-Filho, Victor; Eluf-Neto, José; Fernandez, Leticia; Boccia, Stefania; Hashibe, Mia; Hayes, Richard B; Boffetta, Paolo; Brennan, Paul; McKay, James D; International Agency for Research on Cancer (IARC), 150 Cours Albert Thomas, 69372 Lyon CEDEX 08, France. (2011-04)
      Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35).
    • Skillkenny, the new faculty and good science

      Journal of the Irish Dental Association (Journal of the Irish Dental Association, 2009-04)
    • Smoking cessation and education and the role of the dental hygienist.

      Waldron, C.; Dublin Dental University Hospital (2011)
    • Socioeconomic factors associated with risk of upper aerodigestive tract cancer in Europe.

      Conway, D I; McKinney, P A; McMahon, A D; Ahrens, W; Schmeisser, N; Benhamou, S; Bouchardy, C; Macfarlane, G J; Macfarlane, T V; Lagiou, P; Minaki, P; Bencko, V; Holcátová, I; Merletti, F; Richiardi, L; Kjaerheim, K; Agudo, A; Castellsague, X; Talamini, R; Barzan, L; Canova, C; Simonato, L; Lowry, R J; Znaor, A; Healy, C M; McCartan, B E; Marron, M; Hashibe, M; Brennan, P; Dental School, Faculty of Medicine, University of Glasgow, 378 Sauchiehall Street, Glasgow G2 3JZ, UK. d.conway@dental.gla.ac.uk (2010-02)
      Socioeconomic inequalities for UADT cancers are only observed among men and are not totally explained by smoking, alcohol drinking and diet.
    • Sporting injuries to the temporomandibular joint

      Canavan, Dr Dermot (Irish Dental Association, 2011-08)
    • Stating our values

      Stassen, LF (Journal of the Irish Dental Association, 2009-10)
    • A study of the bone healing kinetics of plateau versus screw root design titanium dental implants.

      Leonard, Gary; Coelho, Paulo; Polyzois, Ioannis; Stassen, Leo; Claffey, Noel; Department of Oral and Maxillofacial Surgery, Trinity College, School of Dental Science, Dublin 2, Ireland. (2009-03)
      The results can be interpreted to indicate a comparable development of secondary stability for both PRF and SRF implant designs. However, as these parameters reflect the structural connection between implant and bone and not the functional properties of the bone to implant interface, they cannot be regarded as comprehensive measures of osseointegration. This particularly relevant given the reduced load bearing capacity of woven bone.
    • A subcutaneous mandibulotomy approach for a salivary clear cell carcinoma of the retromolar trigone.

      Fennessy, B G; Sheahan, P; Toner, M; Timon, C; Department of Otorhinolaryngology Head and Neck Surgery, St James Hospital, Dublin 8, Ireland. brendanfennessy@yahoo.com (2010-03)
      This is the first occasion a subcutaneous mandibulotomy approach for an oral tumour has been described in Great Britain and Ireland, the second reported case of clear cell carcinoma originating in the retromolar trigone region and only the fourth case of associated lymph nodal metastases.
    • Supernumerary pre-molar teeth in the mandible.

      O'Dowling, Ian (Irish Dental Association, 2009-12)
    • Surgical therapy for the control of peri-implantitis.

      Renvert, Stefan; Polyzois, Ioannis; Claffey, Noel; Department of Health Sciences, Kristianstad University, Kristianstad, Sweden. stefan.renvert@hkr.se (2012-10)
      Articles on surgical treatment of peri-implantitis in humans published up to December 2011 were included.
    • A survey to assess the provision of conscious sedation by general dental practitioners in the Republic of Ireland.

      Fisher, Veronica; Stassen, Leo F A; Nunn, June; Department of Oral and Maxillofacial Surgery, Dublin Dental School and Hospital, Lincoln Place, Dublin 2. VFisher@dental.tcd.ie (2011-04)
      The data from this study indicated the need for postgraduate training in conscious sedation in Ireland and a need for increased awareness of the Dental Council Code of Practice on sedation.
    • Technique tips--management of a de-bonded, fixed-fixed, resin-bonded bridge.

      Alkadhimi, Aslam Fadel; Ashkanani, Mohammad; Sultan, Ahmed; Warreth, Abdulhadi; Restorative and Periodontology Division, Dublin Dental University Hospital, Dublin, Ireland. (2012-09)