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A Multi-Center Prospective Derivation and Validation of a Clinical Prediction Tool for Severe Clostridium difficile Infection.Na, Xi; Martin, Alan J; Sethi, Saurabh; Kyne, Lorraine; Garey, Kevin W; Flores, Sarah W; Hu, Mary; Shah, Dhara N; Shields, Kelsey; Leffler, Daniel A; et al. (Public Library of Science (PLoS One), 2015-04-23)Prediction of severe clinical outcomes in Clostridium difficile infection (CDI) is important to inform management decisions for optimum patient care. Currently, treatment recommendations for CDI vary based on disease severity but validated methods to predict severe disease are lacking. The aim of the study was to derive and validate a clinical prediction tool for severe outcomes in CDI.