Frontonasal dysmorphology in bipolar disorder by 3D laser surface imaging and geometric morphometrics: comparisons with schizophrenia.
AffiliationMolecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St. Stephen's Green, Dublin 2, Ireland.
Local subject classificationBIPOLAR DISORDER
Analysis of Variance
Principal Component Analysis
MetadataShow full item record
CitationFrontonasal dysmorphology in bipolar disorder by 3D laser surface imaging and geometric morphometrics: comparisons with schizophrenia. 2010, 122 (1-3):63-71 Schizophr. Res.
AbstractAny developmental relationship between bipolar disorder and schizophrenia engenders continuing debate. As the brain and face emerge in embryological intimacy, brain dysmorphogenesis is accompanied by facial dysmorphogenesis. 3D laser surface imaging was used to capture the facial surface of 13 male and 14 female patients with bipolar disorder in comparison with 61 male and 75 female control subjects and with 37 male and 32 female patients with schizophrenia. Surface images were analysed using geometric morphometrics and 3D visualisations to identify domains of facial shape that distinguish bipolar patients from controls and bipolar patients from those with schizophrenia. Both male and female bipolar patients evidenced significant facial dysmorphology: common to male and female patients was overall facial widening, increased width of nose, narrowing of mouth and upward displacement of the chin; dysmorphology differed between male and female patients for nose length, lip thickness and tragion height. There were few morphological differences in comparison with schizophrenia patients. That dysmorphology of the frontonasal prominences and related facial regions in bipolar disorder is more similar to than different from that found in schizophrenia indicates some common dysmorphogenesis. Bipolar disorder and schizophrenia might reflect similar insult(s) acting over slightly differing time-frames or slightly differing insult(s) acting over a similar time-frame.
- Three-dimensional laser surface imaging and geometric morphometrics resolve frontonasal dysmorphology in schizophrenia.
- Authors: Hennessy RJ, Baldwin PA, Browne DJ, Kinsella A, Waddington JL
- Issue date: 2007 May 15
- Refining the resolution of craniofacial dysmorphology in bipolar disorder as an index of brain dysmorphogenesis.
- Authors: Katina S, Kelly BD, Rojas MA, Sukno FM, McDermott A, Hennessy RJ, Lane A, Whelan PF, Bowman AW, Waddington JL
- Issue date: 2020 Sep
- Craniofacial dysmorphology in 22q11.2 deletion syndrome by 3D laser surface imaging and geometric morphometrics: illuminating the developmental relationship to risk for psychosis.
- Authors: Prasad S, Katina S, Hennessy RJ, Murphy KC, Bowman AW, Waddington JL
- Issue date: 2015 Mar
- 3D morphometrics of craniofacial dysmorphology reveals sex-specific asymmetries in schizophrenia.
- Authors: Hennessy RJ, Lane A, Kinsella A, Larkin C, O'Callaghan E, Waddington JL
- Issue date: 2004 Apr 1
- Facial morphometrics of children with non-syndromic orofacial clefts in Tanzania.
- Authors: Manyama M, Larson JR, Liberton DK, Rolian C, Smith FJ, Kimwaga E, Gilyoma J, Lukowiak KD, Spritz RA, Hallgrimsson B
- Issue date: 2014 Jul 29