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    Pilomatrix carcinoma presenting as an extra axial mass: clinicopathological features.

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    Authors
    Aherne, Noel J
    Fitzpatrick, David A
    Gibbons, David
    Armstrong, John G
    Affiliation
    Department of Radiation Oncology, St. Luke's Hospital, Dublin, Ireland. naherne@gmail.com
    Issue Date
    2008
    
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    Citation
    Pilomatrix carcinoma presenting as an extra axial mass: clinicopathological features. 2008, 3:47 Diagn Pathol
    Publisher
    BioMed Central
    Journal
    Diagnostic pathology
    URI
    http://hdl.handle.net/10147/107081
    DOI
    10.1186/1746-1596-3-47
    PubMed ID
    19040752
    Additional Links
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633279/?tool=pubmed
    Abstract
    Pilomatrix carcinoma is the rare malignant counterpart of pilomatrixoma, a skin adnexal tumour originating from hair matrix cells. Pilomatrix carcinoma can arise as a solitary lesion de novo, or through transformation of a pilomatrixoma. Pilomatrixoma was first described erroneously as being of sebaceous gland origin but was later discovered to be derived from hair matrix cells. They are rare, slow growing tumours of the skin found in the lower dermis and subcutaneous fat and are predominantly found in the neck and the scalp. While known to be locally aggressive, no malignant form was thought to exist until it was described relatively recently. Since then, approximately ninety cases of pilomatrix carcinoma have been reported.We report the case of a 41 year old mentally retarded male who had a longstanding lesion in the left neck for approximately fifteen years previously diagnosed as a pilomatrixoma. He presented with severe headache, falls and visual disturbance and a biopsy showed pilomatrix carcinoma of the occipital region which, on computed tomography ( CT ) invaded the occipital bone, the cerebellum and the left temporal lobe. At his initial presentation he had a craniotomy and subtotal excision of the lesion but received no adjuvant therapy. After an early intracranial recurrence he had further debulking and adjuvant external beam radiotherapy. He has had no further intracranial recurrence after three and a half years of follow-up. Here we present the pathological features of this uncommon tumour.
    Item Type
    Article
    Language
    en
    Series/Report no.
    SKIN CANCER
    CANCER
    ISSN
    1746-1596
    ae974a485f413a2113503eed53cd6c53
    10.1186/1746-1596-3-47
    Scopus Count
    Collections
    St. Luke's Radiation Oncology Network, Dublin

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