Update of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008.
AuthorsKuijper, E J
Brazier, J S
Lambert, M L
Brown, D J
Coia, J E
Widmer, A F
Olsen, K E
Notermans, D W
Poxton, I R
Monnet, D L
AffiliationNational Reference Laboratory for Clostridium difficile. Leiden University Medical Center, Leiden, The Netherlands.
Local subject classificationCLOSTRIDIUM DIFFICILE
Polymerase Chain Reaction
MetadataShow full item record
CitationUpdate of Clostridium difficile infection due to PCR ribotype 027 in Europe, 2008. 2008, 13 (31): Euro Surveill.
JournalEuro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin
AbstractOutbreaks of Clostridium difficile infections (CDI) with increased severity, high relapse rate and significant mortality have been related to the emergence of a new, hypervirulent C. difficile strain in North America and Europe. This emerging strain is referred to as PCR ribotype 027 (Type 027). Since 2005, individual countries have developed surveillance studies about the spread of type 027.C. difficile Type 027 has been reported in 16 European countries. It has been responsible for outbreaks in Belgium, Germany, Finland, France, Ireland, Luxembourg, The Netherlands, Switzerland and the United Kingdom (England, Wales, Northern Ireland and Scotland). It has also been detected in Austria, Denmark, Sweden, Norway, Hungary, Poland and Spain. Three countries experienced imported patients with CDI due to Type 027 who acquired the infection abroad.The antimicrobial resistance pattern is changing, and outbreaks due to clindamycin-resistant ermB positive Type 027 strains have occurred in three European countries. Ongoing epidemiological surveillance of cases of CDI, with periodic characterisation of the strains involved, is required to detect clustering of cases in time and space and to monitor the emergence of new, highly virulent clones.
- Update of Clostridium difficile-associated disease due to PCR ribotype 027 in Europe.
- Authors: Kuijper EJ, Coignard B, Brazier JS, Suetens C, Drudy D, Wiuff C, Pituch H, Reichert P, Schneider F, Widmer AF, Olsen KE, Allerberger F, Notermans DW, Barbut F, Delmée M, Wilcox M, Pearson A, Patel BC, Brown DJ, Frei R, Akerlund T, Poxton IR, Tüll P
- Issue date: 2007 Jun 1
- Increased number of Clostridium difficile infections and prevalence of Clostridium difficile PCR ribotype 001 in southern Germany.
- Authors: Borgmann S, Kist M, Jakobiak T, Reil M, Scholz E, von Eichel-Streiber C, Gruber H, Brazier JS, Schulte B
- Issue date: 2008 Dec 4
- Emergence of Clostridium difficile-associated disease in North America and Europe.
- Authors: Kuijper EJ, Coignard B, Tüll P, ESCMID Study Group for Clostridium difficile., EU Member States., European Centre for Disease Prevention and Control.
- Issue date: 2006 Oct
- Decrease of hypervirulent Clostridium difficile PCR ribotype 027 in the Netherlands.
- Authors: Hensgens MP, Goorhuis A, Notermans DW, van Benthem BH, Kuijper EJ
- Issue date: 2009 Nov 12
- Characterization of toxin A-negative, toxin B-positive Clostridium difficile isolates from outbreaks in different countries by amplified fragment length polymorphism and PCR ribotyping.
- Authors: van den Berg RJ, Claas EC, Oyib DH, Klaassen CH, Dijkshoorn L, Brazier JS, Kuijper EJ
- Issue date: 2004 Mar