Cellular reprogramming by gram-positive bacterial components: a review.
Buckley, Julliette M Wang, Jiang Huai Redmond, H Paul
Buckley, Julliette M
Wang, Jiang Huai
Redmond, H Paul
Advisors
Editors
Other Contributors
Date
2012-02-03T15:04:42Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Animals
Cytokines/biosynthesis/drug effects
Gram-Positive Bacteria/*immunology
Humans
Immune Tolerance/immunology
Lipopolysaccharides/immunology/*pharmacology
Lipoproteins/*pharmacology
Receptors, Cell Surface/biosynthesis/*drug effects/immunology
Signal Transduction/*drug effects/immunology
Teichoic Acids/*pharmacology
Cytokines/biosynthesis/drug effects
Gram-Positive Bacteria/*immunology
Humans
Immune Tolerance/immunology
Lipopolysaccharides/immunology/*pharmacology
Lipoproteins/*pharmacology
Receptors, Cell Surface/biosynthesis/*drug effects/immunology
Signal Transduction/*drug effects/immunology
Teichoic Acids/*pharmacology
Planned Date
Start Date
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Principal Investigators
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Abstract
LPS tolerance has been the focus of extensive scientific and clinical research over the last several decades in an attempt to elucidate the sequence of changes that occur at a molecular level in tolerized cells. Tolerance to components of gram-positive bacterial cell walls such as bacterial lipoprotein and lipoteichoic acid is a much lesser studied, although equally important, phenomenon. This review will focus on cellular reprogramming by gram-positive bacterial components and examines the alterations in cell surface receptor expression, changes in intracellular signaling, gene expression and cytokine production, and the phenomenon of cross-tolerance.
Language
eng
ISSN
0741-5400 (Print)
0741-5400 (Linking)
0741-5400 (Linking)
eISSN
ISBN
DOI
10.1189/jlb.0506312
PMID
16885502