Publication

Immunology. Therapeutic manipulation of gut flora.

Shanahan, F
Author
Shanahan, F
Advisors
Editors
Other Contributors
Departments
Department of Medicine, Cork University Hospital, Cork, Ireland. fshanahan@ucc.ie
Date
2012-02-03T15:12:36Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Animals
Genetic Engineering
Humans
Immunity, Mucosal
Inflammatory Bowel Diseases/*immunology/*therapy
Interleukin-10/administration & dosage/*biosynthesis/genetics/immunology
Intestinal Mucosa/immunology/microbiology
Intestines/immunology/*microbiology
Lactococcus lactis/*genetics/immunology/metabolism
Mice
Probiotics/*therapeutic use
Recombinant Proteins/administration & dosage/biosynthesis/immunology
T-Lymphocyte Subsets/immunology
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
URI
https://hdl.handle.net/10147/209113
Abstract
In developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders (Steidler et al.).
Language
eng
Citation
Science. 2000 Aug 25;289(5483):1311-2.
ISSN
0036-8075 (Print)
0036-8075 (Linking)
eISSN
ISBN
DOI
PMID
10979858
PMCID
Sponsorships
Funding Sources
Funding Amounts
Grant Identifiers
Methodology
Duration
Ethical Approval