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Hypophysitis secondary to ruptured Rathke's cyst mimicking neurosarcoidosis.
Janeczko, Cassandra McHugh, John Rawluk, Daniel Farrell, Michael Brennan, Paul Delanty, Norman
Janeczko, Cassandra
McHugh, John
Rawluk, Daniel
Farrell, Michael
Brennan, Paul
Delanty, Norman
Advisors
Editors
Other Contributors
Date
2009-04
Date Submitted
Keywords
Other Subjects
Subject Mesh
Aneurysm, Ruptured
Central Nervous System Cysts
Female
Humans
Magnetic Resonance Imaging
Middle Aged
Pituitary Diseases
Tomography, X-Ray
Central Nervous System Cysts
Female
Humans
Magnetic Resonance Imaging
Middle Aged
Pituitary Diseases
Tomography, X-Ray
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Hypophysitis secondary to a ruptured Rathke's cyst is rare. We describe a 53-year-old female who presented with headache and subsequently developed aseptic meningitis and panhypopituitarism. MRI findings and concomitant cardiac arrhythmia and peripheral vasculitis led to a provisional diagnosis of neurosarcoidosis. There were no respiratory manifestations of sarcoidosis. Improvement was noted with empirical treatment with steroids. Pituitary biopsy was undertaken to confirm the diagnosis prior to treatment with long-term immunosuppression for putative neurosarcoidosis. The biopsy revealed lymphocytic hypophysitis secondary to a ruptured Rathke's cyst. This report highlights a rare pathology and the importance of a tissue diagnosis before undertaking non-surgical management of a pituitary mass.
Language
en
ISSN
0967-5868
eISSN
ISBN
DOI
10.1016/j.jocn.2008.04.031
PMID
19231195