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Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy.
O'Brien, Sinead M Scully, Paul Fitzgerald, Peter Scott, Lucinda V Dinan, Timothy G
O'Brien, Sinead M
Scully, Paul
Fitzgerald, Peter
Scott, Lucinda V
Dinan, Timothy G
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Editors
Other Contributors
Date
2012-02-03T15:04:47Z
Date Submitted
Keywords
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Subject Mesh
Adult
Analysis of Variance
Antidepressive Agents/*therapeutic use
Cytokines/*blood
Depressive Disorder, Major/*blood/drug therapy
Drug Resistance/*physiology
Enzyme-Linked Immunosorbent Assay/methods
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
Serotonin Uptake Inhibitors/*therapeutic use
Analysis of Variance
Antidepressive Agents/*therapeutic use
Cytokines/*blood
Depressive Disorder, Major/*blood/drug therapy
Drug Resistance/*physiology
Enzyme-Linked Immunosorbent Assay/methods
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
Serotonin Uptake Inhibitors/*therapeutic use
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
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Abstract
OBJECTIVE: Approximately 30% of patients with depression fail to respond to a selective serotonin reuptake inhibitor (SSRI). Few studies have attempted to define these patients from a biological perspective. Studies suggest that overall patients with depression show increased production of proinflammatory cytokines. We examined pro- and anti-inflammatory cytokine levels in patients who were SSRI resistant. METHODS: Plasma concentrations of IL-6, IL-8, IL-10, TNF-alpha and sIL-6R were measured with enzyme linked immunosorbent assays (ELISA) in DSM-1V major depressives who were SSRI resistant, in formerly SSRI resistant patients currently euthymic and in healthy controls. RESULTS: Patients with SSRI-resistant depression had significantly higher production of the pro-inflammatory cytokines IL-6 (p=0.01) and TNF-alpha (p=0.004) compared to normal controls. Euthymic patients who were formerly SSRI resistant had proinflammatory cytokine levels which were similar to the healthy subject group. Anti-inflammatory cytokine levels did not differ across the 3 groups. CONCLUSION: Suppression of proinflammatory cytokines does not occur in depressed patients who fail to respond to SSRIs and is necessary for clinical recovery.
Language
eng
ISSN
0022-3956 (Print)
0022-3956 (Linking)
0022-3956 (Linking)
eISSN
ISBN
DOI
10.1016/j.jpsychires.2006.05.013
PMID
16870211