Rising incidence of renal cell carcinoma in Ireland.
Falebita, Opeyemi A Mancini, Silvia Kiely, Eamonn Comber, Harry
Falebita, Opeyemi A
Mancini, Silvia
Kiely, Eamonn
Comber, Harry
Advisors
Editors
Other Contributors
Date
2009
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell
Female
Humans
Incidence
Ireland
Kidney Neoplasms
Male
Middle Aged
Survival Rate
Aged
Aged, 80 and over
Carcinoma, Renal Cell
Female
Humans
Incidence
Ireland
Kidney Neoplasms
Male
Middle Aged
Survival Rate
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
To determine the trend in the incidence of renal cell carcinoma in Ireland, and evaluate changes in the modes of presentation and outcomes.
Data on all histologically diagnosed renal cancers in Ireland over a 12-year period (1994-2005) were retrieved from the database of the National Cancer Registry of Ireland. Data on all renal cancer deaths in Ireland in the period 1994-2004 were obtained from the Central Statistics Office.
There were 2,485 cases of renal cell carcinoma from 1994 to 2005, of which 64% were in males and 36% in females. The average age of females at diagnosis fell from 63 years in 1994 to 58 years in 2005, with little change in the average age in males. The age-adjusted incidence of renal cell carcinoma per 100,000 person-year increased from 5.2 in 1994 to 6.8 in 2005, an annual percentage change of +3.4%. The percentage of incidental renal cell carcinoma increased from 5% in 1999 to 21% in 2003. The age-adjusted mortality rate for males increased from 4.8 per 100,000 person-year in 1994 to 7.3 in 2004, while that for females decreased from 2.6 to 2.3 in the same period. There was no overall increase in survival over the study period.
While the incidence of renal cell carcinoma is increasing in Ireland, largely, but not entirely, due to an increase in incidentally diagnosed cancers, mortality is increasing in males only.
Data on all histologically diagnosed renal cancers in Ireland over a 12-year period (1994-2005) were retrieved from the database of the National Cancer Registry of Ireland. Data on all renal cancer deaths in Ireland in the period 1994-2004 were obtained from the Central Statistics Office.
There were 2,485 cases of renal cell carcinoma from 1994 to 2005, of which 64% were in males and 36% in females. The average age of females at diagnosis fell from 63 years in 1994 to 58 years in 2005, with little change in the average age in males. The age-adjusted incidence of renal cell carcinoma per 100,000 person-year increased from 5.2 in 1994 to 6.8 in 2005, an annual percentage change of +3.4%. The percentage of incidental renal cell carcinoma increased from 5% in 1999 to 21% in 2003. The age-adjusted mortality rate for males increased from 4.8 per 100,000 person-year in 1994 to 7.3 in 2004, while that for females decreased from 2.6 to 2.3 in the same period. There was no overall increase in survival over the study period.
While the incidence of renal cell carcinoma is increasing in Ireland, largely, but not entirely, due to an increase in incidentally diagnosed cancers, mortality is increasing in males only.
Language
en
ISSN
1573-2584
eISSN
ISBN
DOI
10.1007/s11255-008-9413-0
PMID
18566909