The emerging role of toll-like receptor pathways in surgical diseases.
Romics, Laszlo Jr Szabo, Gyongyi Coffey, John Calvin Wang, Jiang Huai Redmond, Henry Paul
Romics, Laszlo Jr
Szabo, Gyongyi
Coffey, John Calvin
Wang, Jiang Huai
Redmond, Henry Paul
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Date
2012-02-03T15:04:57Z
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Subject Mesh
Animals
Cardiovascular Diseases/immunology
Gastrointestinal Diseases/immunology
Gastrointestinal Tract/immunology
Graft Rejection/immunology
Humans
Neoplasms/immunology
Signal Transduction/physiology
Systemic Inflammatory Response Syndrome/*immunology
Toll-Like Receptors/*physiology
Cardiovascular Diseases/immunology
Gastrointestinal Diseases/immunology
Gastrointestinal Tract/immunology
Graft Rejection/immunology
Humans
Neoplasms/immunology
Signal Transduction/physiology
Systemic Inflammatory Response Syndrome/*immunology
Toll-Like Receptors/*physiology
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Abstract
OBJECTIVE: To outline the emerging significance of Toll-like receptor (TLR) signaling pathways in surgical diseases. DATA SOURCES: A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966 to 2005 without language restriction. STUDY SELECTION: Original or review articles that described experimental data on the activation of TLR signaling pathways in surgically relevant diseases were selected for inclusion in this review. DATA EXTRACTION: Data were obtained from peer-reviewed articles and references. DATA SYNTHESIS: The role of TLRs in the recognition of pathogens renders them a key figure in the activation of both innate and adaptive immune responses during sepsis. However, emerging evidence points to fundamentally important roles in ulcerative colitis, Crohn disease, and Helicobacter pylori infection in the gastrointestinal tract and in the development of atherosclerotic plaques in the cardiovascular system. Furthermore, recent studies suggest that the regulation of the TLR pathway fulfills a central role in anticancer immunotherapy and in organ rejection after transplantation. CONCLUSION: Given the clinical significance of TLR pathways, the targeting of individual molecular components is likely to offer a broad range of future therapeutic modalities.
Language
eng
Citation
ISSN
0004-0010 (Print)
0004-0010 (Linking)
0004-0010 (Linking)
eISSN
ISBN
DOI
10.1001/archsurg.141.6.595
PMID
16785361