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Long-term statin therapy in patients with systolic heart failure and normal cholesterol: effects on elevated serum markers of collagen turnover, inflammation, and B-type natriuretic peptide.
Abulhul, Esam McDonald, Kenneth Martos, Ramon Phelan, Dermot Spiers, J Paul Hennessy, Martina Baugh, John Watson, Chris O'Loughlin, Christina Ledwidge, Mark
Abulhul, Esam
McDonald, Kenneth
Martos, Ramon
Phelan, Dermot
Spiers, J Paul
Hennessy, Martina
Baugh, John
Watson, Chris
O'Loughlin, Christina
Ledwidge, Mark
Advisors
Editors
Other Contributors
Date
2012-01
Date Submitted
Keywords
Other Subjects
Subject Mesh
Aged
Aged, 80 and over
Analysis of Variance
Biological Markers
Chi-Square Distribution
Cholesterol
Collagen
Collagen Type I
Down-Regulation
Female
Heart Failure, Systolic
Heptanoic Acids
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inflammation Mediators
Ireland
Male
Middle Aged
Natriuretic Peptide, Brain
Peptide Fragments
Peptides
Procollagen
Prospective Studies
Pyrroles
Recovery of Function
Stroke Volume
Time Factors
Treatment Outcome
Up-Regulation
Ventricular Function, Left
Aged, 80 and over
Analysis of Variance
Biological Markers
Chi-Square Distribution
Cholesterol
Collagen
Collagen Type I
Down-Regulation
Female
Heart Failure, Systolic
Heptanoic Acids
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Inflammation Mediators
Ireland
Male
Middle Aged
Natriuretic Peptide, Brain
Peptide Fragments
Peptides
Procollagen
Prospective Studies
Pyrroles
Recovery of Function
Stroke Volume
Time Factors
Treatment Outcome
Up-Regulation
Ventricular Function, Left
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
The role of statin therapy in heart failure (HF) is unclear. The amino-terminal propeptide of procollagen type III (PIIINP) predicts outcome in HF, and yet there are conflicting reports of statin therapy effects on PIIINP.
Language
en
ISSN
1879-114X
eISSN
ISBN
DOI
10.1016/j.clinthera.2011.11.002
PMID
22154198