Cytokine orchestration in post-operative peritoneal adhesion formation.
Cahill, Ronan A Redmond, H Paul
Cahill, Ronan A
Redmond, H Paul
Author
Advisors
Editors
Other Contributors
Date
2012-02-03T15:05:05Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Biomedical Research
Cytokines/antagonists & inhibitors/*metabolism
Drugs, Investigational/therapeutic use
Humans
Laparotomy/*adverse effects
Peritoneal Diseases/drug therapy/etiology/*immunology/pathology
Tissue Adhesions
Treatment Outcome
Cytokines/antagonists & inhibitors/*metabolism
Drugs, Investigational/therapeutic use
Humans
Laparotomy/*adverse effects
Peritoneal Diseases/drug therapy/etiology/*immunology/pathology
Tissue Adhesions
Treatment Outcome
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Peritoneal adhesions are a near inevitable occurrence after laparotomy and a major cause of both patient and physician misery. To date, clinical attempts at their amelioration have concentrated on manipulating the physical factors that affect their development despite a wealth of experimental data elucidating the molecular mechanisms that underlie their initiation, development and maturation. However, the advent of targeted, specific anti-cytokine agents as directed therapy for inflammatory and neoplastic conditions raises the prospect of a new era for anti-adhesion strategies. To harness this potential will require considerable cross-disciplinary collaboration and that surgeon-scientists propel themselves to the forefront of this emerging field.
Language
eng
ISSN
1007-9327 (Print)
1007-9327 (Linking)
1007-9327 (Linking)
eISSN
ISBN
DOI
PMID
18756592