Immunonutrition: the role of taurine.
Redmond, H P Stapleton, P P Neary, P Bouchier-Hayes, D
Redmond, H P
Stapleton, P P
Neary, P
Bouchier-Hayes, D
Advisors
Editors
Other Contributors
Date
2012-02-03T15:14:25Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Homeostasis
Humans
*Immunity
*Nutritional Physiological Phenomena
Postoperative Period
Reperfusion Injury
Sepsis
Taurine/*physiology/therapeutic use
Humans
*Immunity
*Nutritional Physiological Phenomena
Postoperative Period
Reperfusion Injury
Sepsis
Taurine/*physiology/therapeutic use
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Taurine is a sulfonated beta amino acid derived from methionine and cysteine metabolism. It is present in high concentrations in most tissues and in particular in proinflammatory cells such as polymorphonuclear phagocytes. Initial investigation into the multifaceted properties of this non-toxic physiologic amino acid revealed a link between retinal dysfunction and dietary deficiency. Since then a role for this amino acid has been found in membrane stabilization, bile salt formation, antioxidation, calcium homeostasis, growth modulation, and osmoregulation. Our own group has demonstrated a key role for taurine in modulation of apoptosis in a variety of cell types. This review summarizes our current knowledge of taurine in nutrition, host proinflammatory cell homeostasis, therapeutic applications, and its potential immunoregulatory properties. It is our belief that taurine, similar to arginine and glutamine, is now more than worthy of critical clinical analysis.
Language
eng
ISSN
0899-9007 (Print)
0899-9007 (Linking)
0899-9007 (Linking)
eISSN
ISBN
DOI
PMID
9684263