[Significance of Toll-like receptors in the pathophysiology of surgical sepsis].
Romics, Laszlo Jr Coffey, John Calvin Wang, Jiang Huai Redmond, Henry Paul Szabo, Gyongyi
Romics, Laszlo Jr
Coffey, John Calvin
Wang, Jiang Huai
Redmond, Henry Paul
Szabo, Gyongyi
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Other Contributors
Date
2012-02-03T15:07:56Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Humans
Membrane Glycoproteins/*metabolism
Receptors, Cell Surface/*metabolism
Sepsis/etiology/*metabolism
*Signal Transduction
Surgical Wound Infection/*metabolism
Toll-Like Receptors
Membrane Glycoproteins/*metabolism
Receptors, Cell Surface/*metabolism
Sepsis/etiology/*metabolism
*Signal Transduction
Surgical Wound Infection/*metabolism
Toll-Like Receptors
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Start Date
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Principal Investigators
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Abstract
The discovery of Toll-like receptors has substantially changed our knowledge of pathogen recognition. 11 Toll-like receptors have so far been described in humans. These recognize distinct pathogen associated molecular patterns, as well as endogenous ligands and small molecular synthetic compounds. TLRs have a multifunctional role in pathogen-triggered immune responses and represent an important connection between the "innate" and "adaptive" immunity. The role of the TLRs in the recognition of pathogens renders them a key figure in the activation of the immune response during surgical sepsis. However, emerging evidence points to a fundamental role in tumorigenesis, transplantation, wound healing, atherogenesis and inflammatory bowel disease. The aim hence was to review experimental data pertaining to the activation of TLR signalling pathways in conditions associated with surgical sepsis. A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966-2004 without language restriction. The paper also analyses the possible therapeutic utilization of the TLR signalling pathways in surgical sepsis.
Language
hun
Citation
ISSN
0025-0295 (Print)
0025-0295 (Linking)
0025-0295 (Linking)
eISSN
ISBN
DOI
PMID
15570917