Enhanced ex vivo inhibition of platelet function following addition of dipyridamole to aspirin after transient ischaemic attack or ischaemic stroke: first results from the TRinity AntiPlatelet responsiveness (TrAP) study.
Tobin, William Oliver Kinsella, Justin A Collins, Daniel Ronan Coughlan, Tara O'Neill, Desmond Egan, Bridget Tierney, Sean Feeley, Thomas Martin Murphy, Raymond P McCabe, Dominick J H
Tobin, William Oliver
Kinsella, Justin A
Collins, Daniel Ronan
Coughlan, Tara
O'Neill, Desmond
Egan, Bridget
Tierney, Sean
Feeley, Thomas Martin
Murphy, Raymond P
McCabe, Dominick J H
Advisors
Editors
Other Contributors
Date
2012-02-01T10:49:11Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Aged
Aspirin/*pharmacology/therapeutic use
Blood Platelets/*drug effects/physiology
Blood Specimen Collection/methods
Dipyridamole/*pharmacology/therapeutic use
Drug Therapy, Combination
Female
Humans
Ischemic Attack, Transient/*blood/drug therapy
Longitudinal Studies
Male
Middle Aged
Platelet Activation/drug effects
Platelet Aggregation Inhibitors/*pharmacology/therapeutic use
Platelet Function Tests
Stroke/*blood/drug therapy
Aged
Aspirin/*pharmacology/therapeutic use
Blood Platelets/*drug effects/physiology
Blood Specimen Collection/methods
Dipyridamole/*pharmacology/therapeutic use
Drug Therapy, Combination
Female
Humans
Ischemic Attack, Transient/*blood/drug therapy
Longitudinal Studies
Male
Middle Aged
Platelet Activation/drug effects
Platelet Aggregation Inhibitors/*pharmacology/therapeutic use
Platelet Function Tests
Stroke/*blood/drug therapy
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Ex vivo dipyridamole 'non-responsiveness' has not been extensively studied in ischaemic cerebrovascular disease. Platelet surface marker expression, leucocyte-platelet complex formation and inhibition of platelet function at high shear stress as detected by the PFA-100(R) Collagen-Adenosine-diphosphate (C-ADP) and Collagen-Epinephrine cartridges was assessed in 52 patients within 4 weeks of transient ischaemic attack (TIA) or ischaemic stroke on aspirin, and then 14 d (14 d) and >90 d (90 d) after adding dipyridamole. A novel definition of 'Dipyridamole non-responsiveness' was used. The median C-ADP closure time increased following addition of dipyridamole, remained elevated at 90 d (P /= 0.5), at 14 and 90 d versus baseline. Additional inhibition of platelet function has been detected with the PFA-100 when dipyridamole is added to aspirin. Elevated monocyte-platelet complexes may contribute to ex vivo dipyridamole non-responsiveness.
Language
eng
ISSN
1365-2141 (Electronic)
0007-1048 (Linking)
0007-1048 (Linking)
eISSN
ISBN
DOI
10.1111/j.1365-2141.2010.08539.x
PMID
21223254