Obstructive sleep apnea in chronic obstructive pulmonary disease patients.
Lee, Ruth McNicholas, Walter T
Lee, Ruth
McNicholas, Walter T
Authors
Advisors
Editors
Other Contributors
Date
2011-03
Date Submitted
Keywords
Other Subjects
Subject Mesh
Anoxia
Cardiovascular Diseases
Comorbidity
Humans
Hypercapnia
Inflammation
Oxidative Stress
Prevalence
Pulmonary Disease, Chronic Obstructive
Sleep Apnea, Obstructive
Syndrome
Cardiovascular Diseases
Comorbidity
Humans
Hypercapnia
Inflammation
Oxidative Stress
Prevalence
Pulmonary Disease, Chronic Obstructive
Sleep Apnea, Obstructive
Syndrome
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) represent two of the most prevalent chronic respiratory disorders and cardiovascular diseases are major co-morbidities in both. Co-existence of both disorders (overlap syndrome) occurs in 1% of adults and overlap patients have worse nocturnal hypoxemia and hypercapnia than COPD and OSA patients alone. The present review discusses recent data concerning the pathophysiological and clinical significance of the overlap syndrome.
The severity of obstructive ventilatory impairment and hyperinflation, especially the inspiratory capacity to total lung capacity (TLC) ratio, correlates with the severity of sleep-related breathing disturbances. Early treatment with continuous positive airway pressure (CPAP) improves survival, reduces hospitalization and pulmonary hypertension, and also reduces hypoxemia. Evidence of systemic inflammation and oxidative stress in COPD and sleep apnea provides insight into potential interactions between both disorders that may predispose to cardiovascular disease. Long-term outcome studies of overlap patients currently underway should provide further evidence of the clinical significance of the overlap syndrome.
Studies of overlap syndrome patients at a clinical, physiological and molecular level should provide insight into disease mechanisms and consequences of COPD and sleep apnea, in addition to identifying potential relationships with cardiovascular disease.
The severity of obstructive ventilatory impairment and hyperinflation, especially the inspiratory capacity to total lung capacity (TLC) ratio, correlates with the severity of sleep-related breathing disturbances. Early treatment with continuous positive airway pressure (CPAP) improves survival, reduces hospitalization and pulmonary hypertension, and also reduces hypoxemia. Evidence of systemic inflammation and oxidative stress in COPD and sleep apnea provides insight into potential interactions between both disorders that may predispose to cardiovascular disease. Long-term outcome studies of overlap patients currently underway should provide further evidence of the clinical significance of the overlap syndrome.
Studies of overlap syndrome patients at a clinical, physiological and molecular level should provide insight into disease mechanisms and consequences of COPD and sleep apnea, in addition to identifying potential relationships with cardiovascular disease.
Language
en
ISSN
1531-6971
eISSN
ISBN
DOI
10.1097/MCP.0b013e32834317bb
PMID
21169840