Creutzfeldt-Jakob disease in Ireland: epidemiological aspects 1980-2002.
Horan, Gail Keohane, Catherine Molloy, Sophie Howley, Rachel Harney, Michael Heffernan, Josephine McGuigan, Christopher Hutchinson, Michael Brett, Francesca Farrell, Michael
Horan, Gail
Keohane, Catherine
Molloy, Sophie
Howley, Rachel
Harney, Michael
Heffernan, Josephine
McGuigan, Christopher
Hutchinson, Michael
Brett, Francesca
Farrell, Michael
Advisors
Editors
Other Contributors
Date
2012-02-03T15:08:38Z
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Age Distribution
Aged
Creutzfeldt-Jakob Syndrome/*epidemiology
*Epidemiologic Studies
Female
Humans
Ireland/epidemiology
Male
Middle Aged
Population Surveillance
Prospective Studies
Retrospective Studies
Risk Factors
Sex Distribution
Age Distribution
Aged
Creutzfeldt-Jakob Syndrome/*epidemiology
*Epidemiologic Studies
Female
Humans
Ireland/epidemiology
Male
Middle Aged
Population Surveillance
Prospective Studies
Retrospective Studies
Risk Factors
Sex Distribution
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Surveillance for Creutzfeldt-Jakob disease (CJD) has been carried out in the Republic of Ireland since 1980. Initial surveillance was passive and based on consented autopsy confirmation of CJD in patients in whom there was a high index of clinical suspicion. Since 1999, an active surveillance programme involving formal notification of all suspect CJD cases has been in place. The annual mortality rate has increased from 0.34 cases/million in 1980 to 1.27 cases/million in 2001. In all, 29 cases have been pathologically confirmed: 1 had variant CJD (vCJD), 1 had iatrogenic human growth hormone-induced CJD and 1 had fatal insomnia. Sporadic CJD (sCJD) accounted for the remainder. This paper details the change in incidence over 22 years as the surveillance programme in Ireland got under way; the increased incidence is attributed to better case ascertainment, as has occurred in other countries where active surveillance programmes have been established.
Language
eng
ISSN
0014-3022 (Print)
0014-3022 (Linking)
0014-3022 (Linking)
eISSN
ISBN
DOI
10.1159/000077063
PMID
14988606