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Gentamicin dosing in therapeutic hypothermia; a quality improvement initiative

Whitla, L
Fitzgerald, D
Twomey, A
Knowles, S
Murphy, JFA
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2016-01
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PREGNANCY
NEONATE
HYPOTHERMIA
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We read with interest a number of articles on gentamicin dosing in neonates treated with therapeutic hypothermia 1-3 . Therapeutic hypothermia has now become the standard of care for newborn infants with hypoxic-ischaemic encephalopathy. Many of these infants concurrently receive gentamicin. Gentamicin is nephrotoxic and ototoxic at high serum concentrations. We therefore carried out a study in The National Maternity Hospital Holles St to analyse trough and peak gentamicin levels in infants who were cooled and compared them to a control group of non-cooled infants.
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en
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