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Sustained virologic response following HCV eradication in two brothers with X-linked agammaglobulinaemia.
Houlihan, Diarmaid D Storan, Eoin R Lee, John M
Houlihan, Diarmaid D
Storan, Eoin R
Lee, John M
Advisors
Editors
Other Contributors
Date
2009-08-21
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Agammaglobulinemia
Antiviral Agents
Comorbidity
Drug Contamination
Genetic Diseases, X-Linked
Hepatitis C
Humans
Interferon Alfa-2b
Male
Recurrence
Ribavirin
Siblings
Agammaglobulinemia
Antiviral Agents
Comorbidity
Drug Contamination
Genetic Diseases, X-Linked
Hepatitis C
Humans
Interferon Alfa-2b
Male
Recurrence
Ribavirin
Siblings
Planned Date
Start Date
Collaborators
Principal Investigators
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19701978.pdf
Adobe PDF, 532.04 KB
Alternative Titles
Publisher
Abstract
X-linked agammaglobulinaemia (XLA) is a humoral immunodeficiency syndrome characterized from childhood by the absence of circulating B lymphocytes, absent or reduced levels of serum immunoglobulin and recurrent bacterial infections. For many affected patients, regular treatment with immunoglobulin is life saving. Hepatitis C viral (HCV) infection acquired through contaminated blood products is widely described in this patient cohort. The natural history of HCV infection in patients with XLA tends to follow a more rapid and aggressive course compared to immunocompetent individuals. Furthermore, standard anti-viral therapy appears to be less efficacious in this patient cohort. Here we report the cases of two brothers with XLA who contracted HCV through contaminated blood products. They were treated with a six month course of Interferon alpha-2b and Ribavirin. We report a sustained virologic response five years after completing treatment.
Language
en
ISSN
1007-9327
eISSN
ISBN
DOI
PMID
19701978