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Hand weakness in Charcot-Marie-Tooth disease 1X.
Arthur-Farraj, P J Murphy, S M Laura, M Lunn, M P Manji, H Blake, J Ramdharry, G Fox, Z Reilly, M M
Arthur-Farraj, P J
Murphy, S M
Laura, M
Lunn, M P
Manji, H
Blake, J
Ramdharry, G
Fox, Z
Reilly, M M
Advisors
Editors
Other Contributors
Date
2012-07
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adult
Charcot-Marie-Tooth Disease
Connexins
Disability Evaluation
Electromyography
Evoked Potentials, Motor
Female
Hand
Hand Strength
Humans
Male
Median Nerve
Middle Aged
Muscle Weakness
Mutation
Neural Conduction
Retrospective Studies
Sex Factors
Ulnar Nerve
Charcot-Marie-Tooth Disease
Connexins
Disability Evaluation
Electromyography
Evoked Potentials, Motor
Female
Hand
Hand Strength
Humans
Male
Median Nerve
Middle Aged
Muscle Weakness
Mutation
Neural Conduction
Retrospective Studies
Sex Factors
Ulnar Nerve
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
There have been suggestions from previous studies that patients with Charcot-Marie-Tooth disease (CMT) have weaker dominant hand muscles. Since all studies to date have included a heterogeneous group of CMT patients we decided to analyse hand strength in 43 patients with CMT1X. We recorded handedness and the MRC scores for the first dorsal interosseous and abductor pollicis brevis muscles, median and ulnar nerve compound motor action potentials and conduction velocities in dominant and non-dominant hands. Twenty-two CMT1X patients (51%) had a weaker dominant hand; none had a stronger dominant hand. Mean MRC scores were significantly higher for first dorsal interosseous and abductor pollicis brevis in non-dominant hands compared to dominant hands. Median nerve compound motor action potentials were significantly reduced in dominant compared to non-dominant hands. We conclude that the dominant hand is weaker than the non-dominant hand in patients with CMT1X.
Language
en
ISSN
1873-2364
eISSN
ISBN
DOI
10.1016/j.nmd.2012.02.008
PMID
22464564