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An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter.
Lau, Kwok-Fai Perkinton, Michael S Rodriguez, Lilia McLoughlin, Declan M Miller, Christopher C J
Lau, Kwok-Fai
Perkinton, Michael S
Rodriguez, Lilia
McLoughlin, Declan M
Miller, Christopher C J
Advisors
Editors
Other Contributors
Date
2010-08-04
Date Submitted
Keywords
Other Subjects
Subject Mesh
Adaptor Proteins, Signal Transducing
Alzheimer Disease
Animals
Blotting, Northern
Brain
CHO Cells
Cricetinae
Cricetulus
Gene Expression Regulation
Glycogen Synthase Kinase 3
Humans
Multiprotein Complexes
Nerve Tissue Proteins
Promoter Regions, Genetic
Rats
Transcription Factors
Transcription, Genetic
Transfection
Two-Hybrid System Techniques
Alzheimer Disease
Animals
Blotting, Northern
Brain
CHO Cells
Cricetinae
Cricetulus
Gene Expression Regulation
Glycogen Synthase Kinase 3
Humans
Multiprotein Complexes
Nerve Tissue Proteins
Promoter Regions, Genetic
Rats
Transcription Factors
Transcription, Genetic
Transfection
Two-Hybrid System Techniques
Planned Date
Start Date
Collaborators
Principal Investigators
Files
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ukmss31079.pdf
Adobe PDF, 498.98 KB
Alternative Titles
Publisher
Abstract
X11alpha is a neuronal adaptor protein that interacts with the amyloid precursor protein (APP) through a centrally located phosphotyrosine binding domain to inhibit the production of Abeta peptide that is deposited in Alzheimer's disease brains. X11alpha also contains two C-terminal postsynaptic density-95, large discs, zona occludens 1 (PDZ) domains, and we show here that through its PDZ domains, X11alpha interacts with a novel transcription factor, fibrinogen silencer binding protein. Moreover, we show that an X11alpha/fibrinogen silencer binding protein complex signals to the nucleus to repress glycogen synthase kinase-3beta promoter activity. Glycogen synthase kinase-3beta is a favoured candidate kinase for phosphorylating tau in Alzheimer's disease. Our findings show a new function for X11alpha that may impact on Alzheimer's disease pathogenesis.
Language
en
ISSN
1473-558X
eISSN
ISBN
DOI
10.1097/WNR.0b013e32833bfca0
PMID
20531236