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Multiple sclerosis exceptionally presenting as parkinsonism responds to intravenous methylprednisolone.
Saidha, S Mok, T H Butler, M Fanning, N Harrington, H
Saidha, S
Mok, T H
Butler, M
Fanning, N
Harrington, H
Advisors
Editors
Other Contributors
Date
2010-05
Date Submitted
Keywords
Other Subjects
Subject Mesh
Disease Progression
Glucocorticoids
Humans
Magnetic Resonance Imaging
Male
Methylprednisolone
Middle Aged
Multiple Sclerosis
Parkinsonian Disorders
Treatment Outcome
Glucocorticoids
Humans
Magnetic Resonance Imaging
Male
Methylprednisolone
Middle Aged
Multiple Sclerosis
Parkinsonian Disorders
Treatment Outcome
Planned Date
Start Date
Collaborators
Principal Investigators
Alternative Titles
Publisher
Abstract
Parkinsonism due to multiple sclerosis (MS) is rare. In previously reported patients with MS-induced parkinsonism, MS manifested first, followed a typical clinical course, and parkinsonism developed later in the course of the illness. We report a 52-year-old male presenting with parkinsonism as the initial manifestation of MS, in whom a subsequent MS relapse consisted of marked deterioration in parkinsonism, a clinical pattern not previously described in MS. A brain MRI demonstrated involvement of the substantia nigra and basal ganglia. This patient illustrates that the clinical presentation and progression of MS may rarely be characterised by predominating parkinsonian features which are reversible by treatment with intravenous methylprednisolone and interferon beta1a.
Language
en
ISSN
1532-2653
eISSN
ISBN
DOI
10.1016/j.jocn.2009.09.026
PMID
20219377